Association of OPN rs11730582 polymorphism with cancer risk: a meta-analysis

被引：1
作者：
He, Lanlan [1 ]
Wang, Yong [2 ]
机构：
[1] Zhenjiang First Peoples Hosp, Emergency Dept, Zhenjiang 212000, Peoples R China
[2] Southeast Univ, Zhongda Hosp, Dept Intervent Radiol & Vasc Surg, Nanjing, Jiangsu, Peoples R China
来源：
ONCOTARGETS AND THERAPY | 2016年 / 9卷
关键词：
osteopontin; polymorphism; cancer; risk; OSTEOPONTIN PROMOTER POLYMORPHISMS; GENETIC POLYMORPHISMS; CHINESE; SUSCEPTIBILITY; EXPRESSION; METASTASIS; PROGNOSIS; BINDING;
D O I：
10.2147/OTT.S94425
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Purpose: Several molecular epidemiological studies have investigated the association between OPN rs11730582 C>T polymorphism and cancer risk, but the results are inconsistent. Hence, a meta-analysis was conducted to determine the association of this polymorphism with cancer risk. Materials and methods: The related articles were searched in PubMed, Embase, and Chinese National Knowledge Infrastructure databases. Pooled odds ratios and 95% confidence intervals were calculated to evaluate the strength of the associations. A random-effects model or fixed-effects model was employed depending on the heterogeneity. Results: A total of ten case-control studies involving 2,749 cancer cases and 3,398 controls were included in the meta-analysis. In overall analysis, OPN rs11730582 C>T polymorphism was not associated with cancer risk. In a stratified analysis by cancer type, no significant association was found between OPN rs11730582 C>T polymorphism and the risk of glioma, gastric cancer, and other cancers. Conclusion: This meta-analysis suggests that OPN rs11730582 C>T polymorphism is not associated with cancer susceptibility.
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收藏
页码：1275 / 1280
页数：6
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