Schizophrenia Genetics

被引：1

作者：

Gareeva, A. E. ^{[1
]}

Khusnutdinova, E. K. ^{[1
]}

机构：

[1] Russian Acad Sci, Inst Biochem & Genet, Ufa Sci Ctr, Ufa 450054, Russia

来源：

RUSSIAN JOURNAL OF GENETICS | 2018年 / 54卷 / 06期

关键词：

schizophrenia; genetics; GENOME-WIDE ASSOCIATION; DE-NOVO MUTATIONS; CASE-CONTROL SAMPLES; BIPOLAR DISORDER; PARANOID SCHIZOPHRENIA; SUSCEPTIBILITY LOCI; DIFFERENTIAL EXPRESSION; PHARMACOGENETIC MARKERS; TYPICAL NEUROLEPTICS; TARGET CHROMOSOMES;

D O I：

10.1134/S1022795418050046

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Schizophrenia is a complex multifactorial disease, in most cases manifested as a result of the interaction of genetic and psychological factors, as well as certain environmental conditions. However, genetic factors certainly play a determining role in the predisposition to schizophrenia. The coefficient of heritability of schizophrenia is about 80%, which is typical of the most highly inherited multifactorial diseases. This review presents the results of the latest world studies of genetic factors in the development of schizophrenia, including epigenetic, genome-wide association studies, and next generation sequencing.

引用

页码：593 / 603

页数：11

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