Engineering Substrate Topography at the Micro- and Nanoscale to Control Cell Function

被引：1045

作者：

Bettinger, Christopher J. ^{[1
,2
]}

Langer, Robert ^{[1
]}

Borenstein, Jeffrey T. ^{[2
]}

机构：

[1] MIT, Dept Chem Engn, Cambridge, MA 02139 USA

[2] Charles Stark Draper Lab Inc, Ctr Biomed Engn, Cambridge, MA 02139 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 30期

基金：

美国国家卫生研究院;

关键词：

cell adhesion; nanostructures; nanotechnology; tissue engineering; ELECTRON-BEAM LITHOGRAPHY; CORNEAL EPITHELIAL-CELLS; CONTACT GUIDANCE; OSTEOBLAST ADHESION; IN-VITRO; NANOSPHERE LITHOGRAPHY; DIRECTIONAL MIGRATION; CYTOSKELETAL DYNAMICS; ACTIN CYTOSKELETON; ENDOTHELIAL-CELLS;

D O I：

10.1002/anie.200805179

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The interaction of mammalian cells with nanoscale topography has proven to be an important signaling modality in controlling cell function. Naturally occurring nanotopographic structures within the extracellular matrix present surrounding cells with mechanotransductive cues that influence local migration, cell polarization, and other functions. Synthetically nanofabricated topography can also influence cell morphology, alignment, adhesion, migration, proliferation, and cytoskeleton organization. We review the use of in vitro synthetic cell-nanotopography interactions to control cell behavior and influence complex cellular processes, including stem-cell differentiation and tissue organization. Future challenges and opportunities in cell-nanotopography engineering are also discussed, including the elucidation of mechanisms and applications in tissue engineering. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：5406 / 5415

页数：10

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