Convenient 'one-pot' synthesis of 3,4-substituted tetrahydrothiophenes through tandem Michael-Henry and Michael-Michael reactions

被引：31
作者：
Barco, Achille
Baricordi, Nikla
Benetti, Simonetta
De Risi, Carmela
Pollini, Gian Piero
机构：
[1] Univ Ferrara, Dipartmento Chim, I-44100 Ferrara, Italy
[2] Univ Ferrara, Dipartimento Sci Farmaceut, I-44100 Ferrara, Italy
来源：
TETRAHEDRON LETTERS | 2006年 / 47卷 / 46期
关键词：
tandem reactions; Michael reactions; Henry reactions; tetrahydrothiophenes;
D O I：
10.1016/j.tetlet.2006.09.055
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
In situ generated nitro alkenes underwent tandem Michael-Henry and Michael-Michael sequences leading to the 'one-pot' formation of 3,4-substituted tetrahydrothiophenes using the commercially available 1,4-dithiane-2,5-diol (the dimer of merca-ptoacetaldehyde) or its 4-mercapto-2-butenoates derivatives as suitable bifunctional partners, respectively. (c) 2006 Elsevier Ltd. All rights reserved.
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页码：8087 / 8090
页数：4
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