Convenient 'one-pot' synthesis of 3,4-substituted tetrahydrothiophenes through tandem Michael-Henry and Michael-Michael reactions

被引：31

作者：

Barco, Achille

Baricordi, Nikla

Benetti, Simonetta

De Risi, Carmela

Pollini, Gian Piero

机构：

[1] Univ Ferrara, Dipartmento Chim, I-44100 Ferrara, Italy

[2] Univ Ferrara, Dipartimento Sci Farmaceut, I-44100 Ferrara, Italy

来源：

TETRAHEDRON LETTERS | 2006年 / 47卷 / 46期

关键词：

tandem reactions; Michael reactions; Henry reactions; tetrahydrothiophenes;

D O I：

10.1016/j.tetlet.2006.09.055

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In situ generated nitro alkenes underwent tandem Michael-Henry and Michael-Michael sequences leading to the 'one-pot' formation of 3,4-substituted tetrahydrothiophenes using the commercially available 1,4-dithiane-2,5-diol (the dimer of merca-ptoacetaldehyde) or its 4-mercapto-2-butenoates derivatives as suitable bifunctional partners, respectively. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：8087 / 8090

页数：4

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