Giving off Mixed Signals-Distinct Functions of α5β1 and αVβ3 Integrins in Regulating Cell Behaviour

被引：84
作者：
Morgan, Mark R. [1 ]
Byron, Adam [1 ]
Humphries, Martin J. [1 ]
Bass, Mark D. [1 ]
机构：
[1] Univ Manchester, Wellcome Trust Ctr Cell Matrix Res, Fac Life Sci, Manchester M13 9PT, Lancs, England
来源：
IUBMB LIFE | 2009年 / 61卷 / 07期
基金：
英国生物技术与生命科学研究理事会; 英国惠康基金;
关键词：
integrin; signalling; trafficking; endocytosis; focal adhesion; migration; BETA CYTOPLASMIC DOMAIN; MATRIX ADHESIONS; FIBRONECTIN FIBRILLOGENESIS; ALPHA-5-BETA-1; INTEGRIN; DIRECTIONAL MIGRATION; 3D MICROENVIRONMENTS; RECYCLING PATHWAYS; TYROSINE KINASES; MEMBRANE DOMAINS; SRC KINASE;
D O I：
10.1002/iub.200
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The formation, maturation, and dissolution of focal adhesions are basic prerequisites of cell migration and rely on the recruitment, signalling, and endocytosis of integrins. In many instances, extracellular matrix molecules are recognised by a number of integrins, and it is the sequential involvement of different integrins that allows establishment of cell polarity and migration towards a matrix stimulus. In this review, we consider both the similarities and differences between two key fibronectin receptors, alpha(V)beta(3) and alpha(5)beta(1) integrin. By considering the GTPase and kinase signalling and trafficking of two such closely-related receptors, we begin to understand how cell migration is coordinated. (C) 2009 IUBMB IUBMB Life, 61(7): 731-738, 2009
引用
收藏
页码：731 / 738
页数：8
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