Aplysinopsins - Marine Indole Alkaloids: Chemistry, Bioactivity and Ecological Significance

被引：83

作者：

Bialonska, Dobroslawa ^{[1
,3
]}

Zjawiony, Jordan K. ^{[1
,2
]}

机构：

[1] Univ Mississippi, Dept Pharmacognosy, Sch Pharm, University, MS 38677 USA

[2] Univ Mississippi, Pharmaceut Sci Res Inst, University, MS 38677 USA

[3] Jagiellonian Univ, Inst Environm Sci, PL-30387 Krakow, Poland

来源：

MARINE DRUGS | 2009年 / 7卷 / 02期

关键词：

aplysinopsins; natural source; stereochemistry; bioactivity; ecological functions; FAMILY DENDROPHYLLIIDAE; NATURAL-PRODUCTS; SCLERACTINIAN CORALS; SMENOSPONGIA-AUREA; SPONGES; ANALOGS; METABOLITES; ORIGIN; PHOTOISOMERIZATION; DERIVATIVES;

D O I：

10.3390/md7020166

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Aplysinopsins are tryptophan-derived marine natural products isolated from numerous genera of sponges and scleractinian corals, as well as from one sea anemone and one nudibranch. Aplysinopsins are widely distributed in the Pacific, Indonesia, Caribbean, and Mediterranean regions. Up to date, around 30 analogues occurring in Nature have been reported. Natural aplysinopsins differ in the bromination pattern of the indole ring, variation in the structure of the C ring, including the number and position of N-methylation, the presence and configuration of the C-8-C-1' double bond, and the oxidation state of the 2-aminoimidazoline fragment. Aplysinopsins can also occur in the form of dimers. This review summarizes 30 years' research on aplysinopsins. The origin, isolation sources, chemistry, bioactivity, and ecological functions of aplysinopsins are comprehensively reviewed.

引用

页码：166 / 183

页数：18

共 38 条

[1] Novel neuronal nitric oxide synthase (nNOS) selective inhibitor, aplysinopsin-type indole alkaloid, from marine sponge Hyrtios erecta [J].