The Child Behavior Checklist-Pediatric Bipolar Disorder Profile Predicts a Subsequent Diagnosis of Bipolar Disorder and Associated Impairments in ADHD Youth Growing Up: A Longitudinal Analysis

被引:136
作者
Biederman, Joseph [1 ,2 ,3 ]
Petty, Carter R.
Monuteaux, Michael C. [2 ,3 ]
Evans, Margaret
Parcell, Tiffany
Faraone, Stephen V. [4 ,5 ,6 ]
Wozniak, Janet [2 ,3 ]
机构
[1] Massachusetts Gen Hosp, Clin & Res Program Pediat Psychopharmacol, Yawkey Ctr, Boston, MA 02114 USA
[2] Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02114 USA
[3] Harvard Univ, Sch Med, Dept Psychiat, Boston, MA 02115 USA
[4] SUNY Upstate Med Univ, Dept Psychiat, Syracuse, NY USA
[5] SUNY Upstate Med Univ, Dept Neurosci, Syracuse, NY USA
[6] SUNY Upstate Med Univ, Dept Physiol, Syracuse, NY USA
关键词
ATTENTION-DEFICIT HYPERACTIVITY; COMMUNITY MENTAL-HEALTH; PREPUBERTAL CHILDREN; CONDUCT DISORDER; JUVENILE MANIA; CBCL; PREVALENCE; ADOLESCENTS; COMORBIDITY; DEPRESSION;
D O I
10.4088/JCP.08m04821
中图分类号
B849 [应用心理学];
学科分类号
040203 ;
摘要
Objective: To examine the predictive utility of the Child Behavior Checklist-Pediatric Bipolar Disorder (CBCL-PBD) profile to help identify children at risk for bipolar disorder. Method: Subjects were ascertained from 2 identically designed longitudinal case-control family studies of subjects (males and females aged 6-18 years) with DSM-III-R attention-deficit/hyperactivity disorder (ADHD). Based on data from the baseline assessment, ADHD subjects without a lifetime diagnosis of bipolar disorder were stratified by the presence (CBCL-PBD positive. N = 28) or absence (CBCL-PBD negative, N = 176) of a CBCL-PBD score >= 210 (total of attention, aggression, and anxious/depressed subscales). Subjects were comprehensively assessed at follow-up with structured psychiatric interviews. Data were collected from April 1988 to February 2003. Results: Over a mean follow-up period of 7.4 years, a positive CBCL-PBD score predicted subsequent diagnoses of bipolar disorder, major depressive disorder, and conduct disorder, as well as impaired psychosocial functioning and higher risk for psychiatric hospitalization. Conclusions: This work suggests that a positive CBCL-PBD score based on elevations on the attention problems, aggressive behavior, and anxious/depressed subscales predicts subsequent pediatric bipolar disorder and associated syndrome-congruent impairments. if confirmed in other studies, the CBCL-PBD score has the potential to help identify children at high risk to develop bipolar disorder. J Clin Psychiatry 2009:70(5):732-740 (C) Copyright 2009 Physicians Postgraduate Press, Inc.
引用
收藏
页码:732 / 740
页数:9
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