Glycometabolic rearrangements--aerobic glycolysis in pancreatic cancer: causes, characteristics and clinical applications

被引：57

作者：

Cao, Lidong ^{[1
,2
]}

Wu, Jiacheng ^{[1
,2
]}

Qu, Xianzhi ^{[1
,2
]}

Sheng, Jiyao ^{[1
,2
]}

Cui, Mengying ^{[1
,2
]}

Liu, Shui ^{[1
,2
]}

Huang, Xu ^{[3
]}

Xiang, Yien ^{[1
,2
]}

Li, Bingjin ^{[4
]}

Zhang, Xuewen ^{[1
,2
]}

Cui, Ranji ^{[4
]}

机构：

[1] Second Hosp Jilin Univ, Dept Hepatobiliary & Pancreat Surg, Changchun 130041, Peoples R China

[2] Jilin Engn Lab Translat Med Hepatobiliary & Pancr, Changchun 130041, Peoples R China

[3] Jilin Univ, Bethune Hosp 1, Dept Hepatobiliary & Pancreat Surg, Changchun 130021, Peoples R China

[4] Second Hosp Jilin Univ, Jilin Prov Key Lab Mol & Chem Genet, Changchun, Peoples R China

来源：

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH | 2020年 / 39卷 / 01期

基金：

中国博士后科学基金;

关键词：

Malignant tumors; Pancreatic; Glycometabolic; Glycolysis; Exocrine; EPITHELIAL-MESENCHYMAL TRANSITION; ACTIVATED STELLATE CELLS; INDUCIBLE FACTOR-I; DUCTAL ADENOCARCINOMA; ALPHA-ENOLASE; GEMCITABINE RESISTANCE; LACTATE-DEHYDROGENASE; GLUCOSE-METABOLISM; OXIDATIVE STRESS; GENE-EXPRESSION;

D O I：

10.1186/s13046-020-01765-x

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Pancreatic cancer is one of the most malignant tumors worldwide, and pancreatic ductal adenocarcinoma is the most common type. In pancreatic cancer, glycolysis is the primary way energy is produced to maintain the proliferation, invasion, migration, and metastasis of cancer cells, even under normoxia. However, the potential molecular mechanism is still unknown. From this perspective, this review mainly aimed to summarize the current reasonable interpretation of aerobic glycolysis in pancreatic cancer and some of the newest methods for the detection and treatment of pancreatic cancer. More specifically, we reported some biochemical parameters, such as newly developed enzymes and transporters, and further explored their potential as diagnostic biomarkers and therapeutic targets.

引用

页数：22

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