The choroid plexus is an important circadian clock component

被引：143

作者：

Myung, Jihwan ^{[1
,2
,3
,4
,5
]}

Schmal, Christoph ^{[6
,7
]}

Hong, Sungho ^{[2
]}

Tsukizawa, Yoshiaki ^{[8
]}

Rose, Pia ^{[6
,7
]}

Zhang, Yong ^{[9
]}

Holtzman, Michael J. ^{[9
]}

De Schutter, Erik ^{[2
]}

Herzel, Hanspeter ^{[6
,7
]}

Bordyugov, Grigory ^{[6
,7
]}

Takumi, Toru ^{[1
,8
]}

机构：

[1] RIKEN, Brain Sci Inst, Wako, Saitama 3510198, Japan

[2] Okinawa Inst Sci & Technol, Computat Neurosci Unit, Okinawa 9040495, Japan

[3] Taipei Med Univ, Grad Inst Humanities Med, Taipei 11031, Taiwan

[4] Taipei Med Univ, TMU Res Ctr Brain & Consciousness, Taipei 11031, Taiwan

[5] Shuang Ho Hosp, Lab Braintime, New Taipei 23561, Taiwan

[6] Charite, Inst Theoret Biol, D-10115 Berlin, Germany

[7] Humboldt Univ, D-10115 Berlin, Germany

[8] Hiroshima Univ, Sch Med, Dept Anat, Hiroshima 7348551, Japan

[9] Washington Univ, Sch Med, Pulm & Clin Care Med, St Louis, MO 63110 USA

来源：

NATURE COMMUNICATIONS | 2018年 / 9卷

基金：

日本学术振兴会; 日本科学技术振兴机构;

关键词：

SUPRACHIASMATIC NUCLEUS; BEHAVIORAL RHYTHMS; LOCOMOTOR-ACTIVITY; NETWORK DYNAMICS; TIMING SYSTEM; OSCILLATORS; PERIOD; SYNCHRONIZATION; MECHANISMS; EXPRESSION;

D O I：

10.1038/s41467-018-03507-2

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Mammalian circadian clocks have a hierarchical organization, governed by the suprachiasmatic nucleus (SCN) in the hypothalamus. The brain itself contains multiple loci that maintain autonomous circadian rhythmicity, but the contribution of the non-SCN clocks to this hierarchy remains unclear. We examine circadian oscillations of clock gene expression in various brain loci and discovered that in mouse, robust, higher amplitude, relatively faster oscillations occur in the choroid plexus (CP) compared to the SCN. Our computational analysis and modeling show that the CP achieves these properties by synchronization of "twist" circadian oscillators via gap-junctional connections. Using an in vitro tissue coculture model and in vivo targeted deletion of the Bmal1 gene to silence the CP circadian clock, we demonstrate that the CP clock adjusts the SCN clock likely via circulation of cerebrospinal fluid, thus finely tuning behavioral circadian rhythms.

引用

页数：13

共 66 条

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