Tumor Necrosis Factor-α Gene Polymorphisms and Risk of Oral Cancer: Evidence from a Meta-analysis

Numerous studies have been conducted regarding association between TNF-alpha and oral cancer risk, but the results remain controversial. The present meta-analysis is performed to acquire a more precise estimation of relationships. Databases of Pubmed, the Cochrane library and the China National Knowledge Internet (CNKI) were retrieved until August 10, 2013. Pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated with fixed-or random-effect models. The heterogeneity assumption was assessed by I-squared test. Among the eight included case-control studies, all were focused on TNF-alpha-308G>A and four also concerned the TNF-alpha-238G>A polymorphism. It was found that oral cancer risk were significant decreased with the TNF-alpha-308G>A polymorphism in the additive genetic model (GG vs. AA, OR=0.19, 95% CI: [0.04, 1.00], P=0.05, I-2=68.9%) and the dominant genetic model (GG+GA vs. AA, OR=0.22, 95% CI: [0.06, 0.82], P=0.03, I-2=52.4%); however, no significant association was observed in allele contrast (G vs. A, OR=0.70, 95% CI: [0.23, 2.16], P=0.54, I-2=95.9%) and recessive genetic models (GG vs. GA+AA, OR=0.72, 95% CI: [0.33, 1.57], P=0.41, I2=93.1%). For the TNF-alpha-238G>A polymorphism, significant associations with oral cancer risk were found in the allele contrast (G vs. A, OR=2.75, 95% CI: [1.25, 6.04], P=0.01, I-2=0.0%) and recessive genetic models (GG vs. GA+AA, OR=2.23, 95% CI: [1.18, 4.23], P=0.01, I-2=0.0%). Conclusively, this meta-analysis indicates that TNF-alpha polymorphisms may contribute to the risk of oral cancer. Allele G and the GG+GA genotype of TNF-alpha-308G>A may decrease the risk of oral cancer, while allele G and the GG genotype of TNF-alpha-238G>A may cause an increase.