The fate of the cyanobacterial toxin β-N-methylamino-L-alanine in freshwater mussels

被引：44

作者：

Downing, Simone ^{[1
]}

Contardo-Jara, Valeska ^{[2
]}

Pflugmacher, Stephan ^{[2
]}

Downing, Timothy Grant ^{[1
]}

机构：

[1] Nelson Mandela Metropolitan Univ, Dept Biochem & Microbiol, ZA-6013 Port Elizabeth, South Africa

[2] Tech Univ Berlin, Inst Ecol, Dept Ecol Impact Res & Ecotoxicol, D-10587 Berlin, Germany

来源：

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY | 2014年 / 101卷

关键词：

beta-N-methylamino-L-alanine; BMAA; Metabolism; Cyanobacteria; Neurotoxin; Mussels; AMINO-ACID-TRANSPORT; BMAA; BICARBONATE; NEUROTOXIN; BIOACCUMULATION; PATHWAYS; EXPOSURE; ALS;

D O I：

10.1016/j.ecoenv.2013.11.028

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

The cyanobacterial neurotoxin, beta-N-methylamino-L-alanine (BMAA) has been suggested as a causative agent for certain neurodegenerative diseases. This cyanotoxin bioaccumulates in an array of aquatic organisms, in which it occurs as both a free amino acid and in a protein-associated form. This study was intended to investigate the environmental fate of BMAA by examining the metabolism of isotopically labeled BMAA in four freshwater mussel species. All species showed substantial uptake of BMAA from the culture media. Data showed no significant evidence for BMAA catabolism in any of the animals but did suggest metabolism via the reversible covalent modification of BMAA in freshwater mussels, a process that appears to be variable in different species. (C) 2014 Published by Elsevier Inc.

引用

页码：51 / 58

页数：8

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