Theophylline-gentisic acid (1/1)

被引：12

作者：

Aitipamula, Srinivasulu ^{[1
]}

Chow, Pui Shan ^{[1
]}

Tan, Reginald B. H. ^{[1
,2
]}

机构：

[1] ASTAR, Inst Chem & Engn Sci, Jurong Isl 627833, Singapore

[2] Natl Univ Singapore, Dept Chem & Biomol Engn, Singapore 117576, Singapore

来源：

ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE | 2009年 / 65卷

关键词：

CO-CRYSTALS; DRUGS;

D O I：

10.1107/S1600536809031031

中图分类号：

O7 [晶体学];

学科分类号：

0702 ; 070205 ; 0703 ; 080501 ;

摘要：

In the title 1:1 cocrystal, C7H8N4O2 center dot C7H6O4, the anti-asthmatic drug theophylline (systematic name: 1,3-dimethyl-7H-purine-2,6-dione) and a non-steroidal anti-inflammatory drug, gentisic acid (systematic name: 2,5-dihydroxybenzoic acid) crystallize together, forming two-dimensional hydrogen-bonded sheets involving N-H center dot center dot center dot O and O-H center dot center dot center dot N hydrogen bonds. The overall crystal packing features pi-pi stacking interactions [centroid-centroid distance = 3.348 (1) angstrom]. The cocrystal described herein belongs to the class of pharmaceutical cocrystals involving two active pharmaceutical ingredients which has been relatively unexplored to date.

引用

页码：O2126 / U1786

页数：12

共 16 条

[1] Trimorphs of a pharmaceutical cocrystal involving two active pharmaceutical ingredients: potential relevance to combination drugs [J].

Aitipamula, Srinivasulu ;

Chow, Pui Shan ;

Tan, Reginald B. H. .

CRYSTENGCOMM, 2009, 11 (09) :1823-1827

[2]

[Anonymous], 2008, CRYSTALCLEAR

[3]

Barbour L.J., 2001, J SUPRAMOL CHEM, V1, P189, DOI [DOI 10.1016/S1472-7862(02)00030-8, 10.1016/S1472-7862(02)00030-8]

[4] Co-Crystals of the Anti-HIV Drugs Lamivudine and Zidovudine [J].

Bhatt, Prashant M. ;

Azim, Yasser ;

Thakur, Tejencer S. ;

Desiraju, Gautam R. .

CRYSTAL GROWTH & DESIGN, 2009, 9 (02) :951-957

[5] AN EMPIRICAL CORRECTION FOR ABSORPTION ANISOTROPY [J].

BLESSING, RH .

ACTA CRYSTALLOGRAPHICA SECTION A, 1995, 51 :33-38

[6] Sulfa drugs as model cocrystal formers [J].

Caira, Mino R. .

MOLECULAR PHARMACEUTICS, 2007, 4 (03) :310-316

[7]

Childs S. L., 2007, Int. Pat. Number, Patent No. [WO2007/067727 A2, 2007067727]

[8] The salt-cocrystal continuum: The influence of crystal structure on ionization state [J].

Childs, Scott L. ;

Stahly, G. Patrick ;

Park, Aeri .

MOLECULAR PHARMACEUTICS, 2007, 4 (03) :323-338

[9] Crystal engineering of the composition of pharmaceutical phases:: Multiple-component crystalline solids involving carbamazepine [J].

Fleischman, SG ;

Kuduva, SS ;

McMahon, JA ;

Moulton, B ;

Walsh, RDB ;

Rodríguez-Hornedo, N ;

Zaworotko, MJ .

CRYSTAL GROWTH & DESIGN, 2003, 3 (06) :909-919

[10] PHARMACEUTICAL HYDRATES [J].

KHANKARI, RK ;

GRANT, DJW .

THERMOCHIMICA ACTA, 1995, 248 :61-79

← 1 2 →