Cloning and selective expression in brain and kidney of ARNT2 homologous to the Ah receptor nuclear translocator (ARNT)

被引：80

作者：

Drutel, G ^{[1
]}

Kathmann, M ^{[1
]}

Heron, A ^{[1
]}

Schwartz, JC ^{[1
]}

Arrang, JM ^{[1
]}

机构：

[1] UNIV PARIS 05, FAC PHARM, PHYSIOL LAB, PARIS, FRANCE

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1996年 / 225卷 / 02期

关键词：

D O I：

10.1006/bbrc.1996.1176

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Arnt2, a new member of the basic-helix-loop-helix transcription factor family, was cloned from rat brain cDNAs. Its deduced 712 amino acid sequence displays 63% identity with that of the aryl hydrocarbon receptor nuclear translocator (Amt1) that was completely established. Whereas Arnt2 gene expression, established by Northern blotting and in situ hybridization histochemistry, occurred selectively in brain and kidney, that of Arnt1 was ubiquitous, suggesting that the two proteins play distinct roles, presumably via dimerization and DNA binding with different partners. (C) 1996 Academic Press, Inc.

引用

页码：333 / 339

页数：7

共 19 条

[1] PROSITE - A DICTIONARY OF SITES AND PATTERNS IN PROTEINS [J].