Antiarrhythmic Effect of Uridine and Uridine-5'-Monophosphate in Acute Myocardial Ischemia

被引：11

作者：

Bul'on, V. V. ^{[1
]}

Krylova, I. B. ^{[1
]}

Selina, E. N. ^{[1
]}

Rodionova, O. M. ^{[1
]}

Evdokimova, N. R. ^{[1
]}

Sapronov, N. S. ^{[1
]}

Mironova, G. D. ^{[2
]}

机构：

[1] Russian Acad Med Sci, Expt Med Res Inst, Dept Neuropharmacol, North Western Div, St Petersburg P-22, Russia

[2] Russian Acad Sci, Inst Theoret & Expt Biophys, Lab Mitochondrial Transport, Pushchino 142292, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2014年 / 157卷 / 06期

关键词：

myocardium; ischemia; arrhythmias; uridine; uridine-5 '-monophosphate;

D O I：

10.1007/s10517-014-2653-3

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Experiments on rats with acute myocardial ischemia accompanied by early postocclusive arrhythmias have shown normalizing, energy-stabilizing, and antiarrhythmic effects of uridine and uridine-5'-monophosphate. The drugs decreased lactate and restored reserves of glycogen and creatine phosphate depleted by ischemia. Uridine and uridine-5'-monophosphate significantly decreased the severity of ventricular arrhythmias. Both drugs reduced the incidence and duration of fibrillation. Uridine -5'-monophosphate demonstrated most pronounced antifibrillatory effectiveness. We hypothesize that the antiarrhythmic effect of the drugs is determined by their capacity to activate energy metabolism.

引用

页码：728 / 731

页数：4

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