Antiarrhythmic Effect of Uridine and Uridine-5'-Monophosphate in Acute Myocardial Ischemia

被引：11
|
作者：
Bul'on, V. V. [1 ]
Krylova, I. B. [1 ]
Selina, E. N. [1 ]
Rodionova, O. M. [1 ]
Evdokimova, N. R. [1 ]
Sapronov, N. S. [1 ]
Mironova, G. D. [2 ]
机构：
[1] Russian Acad Med Sci, Expt Med Res Inst, Dept Neuropharmacol, North Western Div, St Petersburg P-22, Russia
[2] Russian Acad Sci, Inst Theoret & Expt Biophys, Lab Mitochondrial Transport, Pushchino 142292, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2014年 / 157卷 / 06期
关键词：
myocardium; ischemia; arrhythmias; uridine; uridine-5 '-monophosphate;
D O I：
10.1007/s10517-014-2653-3
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Experiments on rats with acute myocardial ischemia accompanied by early postocclusive arrhythmias have shown normalizing, energy-stabilizing, and antiarrhythmic effects of uridine and uridine-5'-monophosphate. The drugs decreased lactate and restored reserves of glycogen and creatine phosphate depleted by ischemia. Uridine and uridine-5'-monophosphate significantly decreased the severity of ventricular arrhythmias. Both drugs reduced the incidence and duration of fibrillation. Uridine -5'-monophosphate demonstrated most pronounced antifibrillatory effectiveness. We hypothesize that the antiarrhythmic effect of the drugs is determined by their capacity to activate energy metabolism.
引用
收藏
页码：728 / 731
页数：4
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