Prevalence and risk factors for colonization by extended-spectrum β-lactamase-producing or ST 131 Escherichia coli among asymptomatic adults in community settings in Southern Taiwan

被引：17

作者：

Wu, Pin-Chieh ^{[1
,2
]}

Wang, Jiun-Ling ^{[3
,4
]}

Hsueh, Po-Ren ^{[5
,6
]}

Lin, Po-Hsiang ^{[7
]}

Cheng, Ming-Fang ^{[8
,9
,10
,11
,12
]}

Huang, I-Fei ^{[8
]}

Chen, Yao-Shen ^{[9
,13
]}

Lee, Susan Shin-Jung ^{[9
,13
]}

Guang-Yuan, Mar ^{[1
,13
]}

Yu, Hsien-Chung ^{[1
,9
,13
,14
]}

Hsu, Chiao-Lin ^{[1
,2
]}

Wang, Fu-Wei ^{[2
,15
]}

Chen, Chi-Shen ^{[1
]}

Hung, Chih-Hsin ^{[10
,11
]}

Ko, Wen-Chien ^{[3
,4
]}

机构：

[1] Kaohsiung Vet Gen Hosp, Dept Phys Examinat Ctr, Kaohsiung, Taiwan

[2] Meiho Univ, Dept Nursing, Pingtung, Taiwan

[3] Natl Cheng Kung Univ Hosp, Dept Internal Med, Tainan, Taiwan

[4] Natl Cheng Kung Univ, Coll Med, Dept Med, 138 Sheng Li Rd, Tainan 704, Taiwan

[5] Natl Taiwan Univ, Coll Med, Natl Taiwan Univ Hosp, Dept Lab Med, Taipei, Taiwan

[6] Natl Taiwan Univ, Coll Med, Natl Taiwan Univ Hosp, Dept Internal Med, Taipei, Taiwan

[7] Kaohsiung Vet Gen Hosp, Dept Emergency Med, Kaohsiung, Taiwan

[8] Kaohsiung Vet Gen Hosp, Dept Pediat, 386 Dazhong 1st Rd, Kaohsiung 813, Taiwan

[9] Natl Yang Ming Univ, Sch Med, Taipei, Taiwan

[10] I Shou Univ, Dept Chem Engn, Kaohsiung, Taiwan

[11] I Shou Univ, Inst Biotechnol & Chem Engn, Kaohsiung, Taiwan

[12] Fooyin Univ, Dept Nursing, Kaohsiung, Taiwan

[13] Kaohsiung Vet Gen Hosp, Dept Internal Med, Kaohsiung, Taiwan

[14] Natl Sun Yat Sen Univ, Inst Hlth Care Management, Dept Business Management, Kaohsiung, Taiwan

[15] Kaohsiung Vet Gen Hosp, Dept Family Med, Kaohsiung, Taiwan

来源：

INFECTION AND DRUG RESISTANCE | 2019年 / 12卷

关键词：

fecal colonization; extended-spectrum beta-lactamase; sequence type; MCR1; Escherichia coli; SEQUENCE TYPE ST131; FECAL CARRIAGE; MULTIPLEX PCR; ENTEROBACTERIACEAE; INFECTIONS; RESISTANCE; MCR-1; EPIDEMIOLOGY; OUTCOMES; GENES;

D O I：

10.2147/IDR.S201086

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Purpose: Fecal carriage of extended-spectrum beta-lactamase-producing Escherichia coli (ESBL-EC) is common in Asia, especially in China and Southeast Asia. There are no data about fecal carriage of ESBL-EC and mcr-1-positive E. coli in Taiwan, and few studies focusing on the risk factors of asymptomatic fecal carriage of epidemic ST131 E. coli have been published. Patients and methods: From healthy inhabitants attending health examinations at a medical center in southern Taiwan in 2017, we collected 724 stool samples, which were examined for ESBL-EC fecal carriage using chromogenic medium. ST131 and mcr1-positive E. coli were also investigated using multiplex PCR. Clinical data from all participating adults were collected to analyze the risk factors for fecal ESBL-EC or ST131 E. coli carriage. Results: The prevalence rate of asymptomatic ESBL-EC fecal carriage in adults was 1.9% (14/724). ST131 was found in 22 (3.0%) adults and mcr-1-positive E. coli was found in three (0.4%) adults. A multivariate analysis showed that the risk factors associated with ESBL-EC carriage were diabetes mellitus (adjusted odds ratio [aOR]: 5.5, 95% confidence interval [CI]: 1.3-22.7), a history of colonic polyps (aOR: 6.4, 95% CI: 1.6-24.9), and chronic renal insufficiency (aOR: 20.7, 95% CI: 1.4-305.7). Underlying cancer (aOR: 4.8, 95% CI: 1.0-22.5) and stroke (aOR: 18.0, 95% CI: 1.6-207.5) were associated with ST131 E. coli fecal carriage. In our cohort, travel to Asian countries and food habit were not associated with ST131 or ESBL-EC fecal carriage. Conclusions: The ESBL-EC or ST131 E. coli fecal carriage rate is low among asymptomatic adults in Taiwan. Certain underlying medical conditions were associated with their fecal carriage.

引用

页码：1063 / 1071

页数：9

共 34 条

[11] Epidemiology and clinical outcomes of bloodstream infections caused by extended-spectrum β-lactamase-producing Escherichia coli in patients with cancer [J].