Vaccines against human enteric bacterial pathogens

被引：16
作者：
Dougan, G [1 ]
Huett, A [1 ]
Clare, S [1 ]
机构：
[1] Univ London Imperial Coll Sci Technol & Med, Ctr Mol Microbiol & Infect, Dept Biol Sci, London SW7 2AZ, England
来源：
BRITISH MEDICAL BULLETIN | 2002年 / 62卷
关键词：
D O I：
10.1093/bmb/62.1.113
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The development of vaccines against enteric bacterial pathogens presents a challenge because of the large number of pathogens capable of causing disease and the requirement to induce immunity that is effective in the gut. A new generation of enteric vaccines based either on live or non-living antigens delivered orally or by injection are reaching the clinic in the early phases of evaluation. However, considerable technical barriers have to be overcome before these vaccines reach the general population.
引用
收藏
页码：113 / 123
页数：11
相关论文
共 44 条
  • [1] FIELD TRIAL OF ORAL CHOLERA VACCINES IN BANGLADESH - RESULTS FROM 3-YEAR FOLLOW-UP
    CLEMENS, JD
    SACK, DA
    HARRIS, JR
    VANLOON, F
    CHAKRABORTY, J
    AHMED, F
    RAO, MR
    KHAN, MR
    YUNUS, M
    HUDA, N
    STANTON, BF
    KAY, BA
    WALTER, S
    EECKELS, R
    SVENNERHOLM, AM
    HOLMGREN, J
    [J]. LANCET, 1990, 335 (8684) : 270 - 273
  • [2] SAFETY AND IMMUNOGENICITY OF SALMONELLA-TYPHI TY21A VACCINE IN YOUNG THAI CHILDREN
    CRYZ, SJ
    VANPRAPAR, N
    THISYAKORN, U
    OLANRATMANEE, T
    LOSONSKY, G
    LEVINE, MM
    CHEARSKUL, S
    [J]. INFECTION AND IMMUNITY, 1993, 61 (03) : 1149 - 1151
  • [3] Safety and immunogenicity of phoP/phoQ-deleted Salmonella typhi expressing Helicobacter pylori urease in adult volunteers
    DiPetrillo, MD
    Tibbetts, T
    Kleanthous, H
    Killeen, KP
    Hohmann, EL
    [J]. VACCINE, 1999, 18 (5-6) : 449 - 459
  • [4] Intranasal immunogenicity and adjuvanticity of site-directed mutant derivatives of cholera toxin
    Douce, G
    Fontana, M
    Pizza, M
    Rappuoli, R
    Dougan, G
    [J]. INFECTION AND IMMUNITY, 1997, 65 (07) : 2821 - 2828
  • [5] MUTANTS OF ESCHERICHIA-COLI HEAT-LABILE TOXIN LACKING ADP-RIBOSYLTRANSFERASE ACTIVITY ACT AS NONTOXIC, MUCOSAL ADJUVANTS
    DOUCE, G
    TURCOTTE, C
    CROPLEY, I
    ROBERTS, M
    PIZZA, M
    DOMENGHINI, M
    RAPPUOLI, R
    DOUGAN, G
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (05) : 1644 - 1648
  • [6] EFFECT OF PARENTERAL IMMUNIZATION ON THE INTESTINAL IMMUNE-RESPONSE TO SALMONELLA-TYPHI TY21A
    FORREST, BD
    LABROOY, JT
    DEARLOVE, CE
    SHEARMAN, DJC
    [J]. INFECTION AND IMMUNITY, 1992, 60 (02) : 465 - 471
  • [7] EFFECT OF PARENTERAL IMMUNIZATION ON THE INTESTINAL IMMUNE-RESPONSE TO SALMONELLA-TYPHI TY21A AS MEASURED USING PERIPHERAL-BLOOD LYMPHOCYTES
    FORREST, BD
    LABROOY, JT
    [J]. VACCINE, 1993, 11 (02) : 136 - 139
  • [8] Safety and immunogenicity of a proteosome-Shigella flexneri 2a lipopolysaccharide vaccine administered intranasally to healthy adults
    Fries, LF
    Montemarano, AD
    Mallett, CP
    Taylor, DN
    Hale, TL
    Lowell, GH
    [J]. INFECTION AND IMMUNITY, 2001, 69 (07) : 4545 - 4553
  • [9] SIMULTANEOUS EXPRESSION OF CFA/I AND CS3 COLONIZATION FACTOR ANTIGENS OF ENTEROTOXIGENIC ESCHERICHIA-COLI BY DELTA-AROC, DELTA-AROD SALMONELLA-TYPHI VACCINE STRAIN CVD-908
    GIRON, JA
    XU, JG
    GONZALEZ, CR
    HONE, D
    KAPER, JB
    LEVINE, MM
    [J]. VACCINE, 1995, 13 (10) : 939 - 946
  • [10] SALMONELLA-TYPHI VACCINE STRAIN CVD-908 EXPRESSING THE CIRCUMSPOROZOITE PROTEIN OF PLASMODIUM-FALCIPARUM - STRAIN CONSTRUCTION AND SAFETY AND IMMUNOGENICITY IN HUMANS
    GONZALEZ, C
    HONE, D
    NORIEGA, FR
    TACKET, CO
    DAVIS, JR
    LOSONSKY, G
    NATARO, JP
    HOFFMAN, S
    MALIK, A
    NARDIN, E
    SZTEIN, MB
    HEPPNER, DG
    FOUTS, TR
    ISIBASI, A
    LEVINE, MM
    [J]. JOURNAL OF INFECTIOUS DISEASES, 1994, 169 (04) : 927 - 931
12345