Environmental and genetic risk factors for gastric cancer

被引:35
|
作者
Shah, Dhavan [1 ]
Bentrem, David [2 ,3 ]
机构
[1] Northwestern Univ, Feinberg Sch Med, Surg Outcome & Qual Improvement Ctr, Dept Surg, Chicago, IL 60611 USA
[2] Northwestern Univ, Feinberg Sch Med, Dept Surg, Chicago, IL 60611 USA
[3] Jesse Brown VA Med Ctr, Chicago, IL USA
关键词
adenocarcinoma; diet; H; pylori; stomach; HELICOBACTER-PYLORI INFECTION; ABO BLOOD-GROUP; GERMLINE MUTATIONS; CIGARETTE-SMOKING; STOMACH-CANCER; LYNCH-SYNDROME; EPIDEMIOLOGIC EVIDENCE; EXTRACOLONIC CANCERS; ALCOHOL-CONSUMPTION; VEGETABLE INTAKE;
D O I
10.1002/jso.26869
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Gastric cancer is a heterogeneous and prevalent disease. The traditional environmental exposures associated with an elevated risk of gastric cancer are less prevalent in the United States today. Genetic risks and risks associated with inflammation remain. Most cases are sporadic and familial clustering is observed in about 10% of the cases. Hereditary gastric cancer accounts for a very low percentage of cases. Here we review the genetic and environmental risk factors associated with the disease.
引用
收藏
页码:1096 / 1103
页数:8
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