Ganglioside-induced antiganglioside antibodies from a neuropathy patient cross-react with lipopolysaccharides of Campylobacter jejuni associated with Guillain-Barre syndrome

被引：25
作者：
Neisser, A
Schwerer, B
Bernheimer, H
Moran, AP
机构：
[1] Univ Vienna, Inst Neurol, A-1090 Vienna, Austria
[2] Natl Univ Ireland Univ Coll Galway, Dept Microbiol, Galway, Ireland
来源：
JOURNAL OF NEUROIMMUNOLOGY | 2000年 / 102卷 / 01期
关键词：
neuropathy; gangliosides; Campylobacter jejuni lipopolysaccharides; cross-reactive antibodies;
D O I：
10.1016/S0165-5728(99)00159-9
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Antiganglioside serum antibodies from a patient treated with gangliosides were examined for cross-reactivity with lipopolysaccharides (LPSs) of Campylobacter jejuni strains associated with Guillain-Barre syndrome (GBS). The patient had no preceding infection with C. jejuni and developed chronic progressive motor polyneuropathy following parenteral ganglioside treatment. Serum IgG antibodies recognised GM(1) and GD(1b) gangliosides as well as asialo-GM(1), and cross-reactivity was observed with LPSs from C. jejuni O:2, O:4, O:19 and O:41. The results give a clear indication that gangliosides and LPSs from C. jejuni serotypes associated with GBS share common epitopes. (C)2000 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：85 / 88
页数：4
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