Emerging Roles of NPQ/Spexin in Physiology and Pathology

被引：61

作者：

Lv, Shuang-Yu ^{[1
]}

Zhou, Yu-Chen ^{[1
]}

Zhang, Xiao-Mei ^{[1
]}

Chen, Wei-Dong ^{[1
,2
]}

Wang, Yan-Dong ^{[3
]}

机构：

[1] Henan Univ, Sch Med, Key Lab Receptors Mediated Gene Regulat & Drug Di, Kaifeng, Peoples R China

[2] Inner Mongolia Med Univ, Sch Basic Med Sci, Key Lab Mol Pathol, Hohhot, Peoples R China

[3] Beijing Univ Chem Technol, Coll Life Sci & Technol, State Key Lab Chem Resource Engn, Beijing, Peoples R China

来源：

FRONTIERS IN PHARMACOLOGY | 2019年 / 10卷

基金：

中国国家自然科学基金;

关键词：

spexin; NPQ; obesity; metabolism; neuropeptide; RECEPTOR-TYPE II; SPEXIN EXPRESSION; PEPTIDE; GLUCOSE; NEUROPEPTIDE; REGULATOR; GOLDFISH;

D O I：

10.3389/fphar.2019.00457

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Spexin (SPX), also called neuropeptide Q (NPQ), is a novel endogenous neuropeptide. Spexin gene and protein are widely expressed in central nervous system and peripheral tissues in humans, rodents, goldfish, etc. A few of physiological and pathological roles of spexin are gradually emerged recently. This article summarized the roles of spexin in feeding behavior, gastrointestinal motility, obesity, diabetes, energy metabolism, endocrine, mental diseases, and cardiovascular function. Given the broad roles of spexin, this neuropeptide has attracted much interest from investigators and will be as a promising future target for novel therapeutic research and drug design.

引用

页数：7

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