Cell therapy for intervertebral disc herniation and degenerative disc disease: clinical trials

被引：65
作者：
Schol, Jordy [1 ]
Sakai, Daisuke [1 ]
机构：
[1] Tokai Univ, Sch Med, Dept Orthopaed Surg, 143 Shimokasya, Isehara, Kanagawa 2591143, Japan
来源：
INTERNATIONAL ORTHOPAEDICS | 2019年 / 43卷 / 04期
关键词：
Clinical trials; Cell therapy; Regenerative medicine; Intervertebral disc; Degeneration; MESENCHYMAL STEM-CELLS; BONE-MARROW-CELLS; LOW-BACK-PAIN; CHONDROCYTE TRANSPLANTATION; INTRADISCAL INJECTION; MAGNETIC-RESONANCE; LUMBAR FUSION; STROMAL CELLS; REPAIR; MODEL;
D O I：
10.1007/s00264-018-4223-1
中图分类号：
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];
学科分类号：
摘要：
Low back pain is the primary cause of disability and is highly associated with progression of intervertebral disc degeneration. Current treatment options are limited and fail to address the origin of the problem. New advancements in cellular therapies might offer novel and potent strategies for low back pain patients. In this review, we summarize and discuss the contemporary status of in-human trials investigating cellular transplantation for treatment of low back pain. We aim to highlight current trends, shortcomings, and hurdles for effective clinical trials and consecutive commercialization.
引用
收藏
页码：1011 / 1025
页数：15
相关论文
共 64 条
  • [51] Exhaustion of nucleus pulposus progenitor cells with ageing and degeneration of the intervertebral disc
    Sakai, Daisuke
    Nakamura, Yoshihiko
    Nakai, Tomoko
    Mishima, Taishi
    Kato, Shunichi
    Grad, Sibylle
    Alini, Mauro
    Risbud, Makarand V.
    Chan, Danny
    Cheah, Kathryn S. E.
    Yamamura, Ken-ichi
    Masuda, Koichi
    Okano, Hideyuki
    Ando, Kiyoshi
    Mochida, Joji
    [J]. NATURE COMMUNICATIONS, 2012, 3
  • [52] Effect of Cell Number on Mesenchymal Stem Cell Transplantation in a Canine Disc Degeneration Model
    Serigano, Kenji
    Sakai, Daisuke
    Hiyama, Akihiko
    Tamura, Futoshi
    Tanaka, Masahiro
    Mochida, Joji
    [J]. JOURNAL OF ORTHOPAEDIC RESEARCH, 2010, 28 (10) : 1267 - 1275
  • [53] Advancing cell therapies for intervertebral disc regeneration from the lab to the clinic: Recommendations of the ORS spine section
    Smith, Lachlan J.
    Silverman, Lara
    Sakai, Daisuke
    Le Maitre, Christine L.
    Mauck, Robert L.
    Malhotra, Neil R.
    Lotz, Jeffrey C.
    Buckley, Conor T.
    [J]. JOR SPINE, 2018, 1 (04):
  • [54] ROLE OF HYPOXIA AND GROWTH AND DIFFERENTIATION FACTOR-5 ON DIFFERENTIATION OF HUMAN MESENCHYMAL STEM CELLS TOWARDS INTERVERTEBRAL NUCLEUS PULPOSUS-LIKE CELLS
    Stoyanov, J. V.
    Gantenbein-Ritter, B.
    Bertolo, A.
    Aebli, N.
    Baur, M.
    Alini, M.
    Grad, S.
    [J]. EUROPEAN CELLS & MATERIALS, 2011, 21 : 533 - 547
  • [55] Leaping the hurdles in developing regenerative treatments for the intervertebral disc from preclinical to clinical
    Thorpe, Abbey A.
    Bach, Frances C.
    Tryfonidou, Marianna A.
    Le Maitre, Christine L.
    Mwale, Fackson
    Diwan, Ashish D.
    Ito, Keita
    [J]. JOR SPINE, 2018, 1 (03):
  • [56] Tschugg A, 2017, NEUROSURG REV, V40, P155, DOI 10.1007/s10143-016-0781-0
  • [57] A prospective multicenter phase I/II clinical trial to evaluate safety and efficacy of NOVOCART Disc plus autologous disc chondrocyte transplantation in the treatment of nucleotomized and degenerative lumbar disc to avoid secondary disease: study protocol for a randomized controlled trial
    Tschugg, Anja
    Michnacs, Felix
    Strowitzki, Martin
    Meisel, Hans Joerg
    Thome, Claudius
    [J]. TRIALS, 2016, 17
  • [58] The Transpedicular Approach As an Alternative Route for Intervertebral Disc Regeneration
    Vadala, Gianluca
    Russo, Fabrizio
    Pattappa, Girish
    Schiuma, Damiano
    Peroglio, Marianna
    Benneker, Lorin M.
    Grad, Sibylle
    Alini, Mauro
    Denaro, Vincenzo
    [J]. SPINE, 2013, 38 (06) : E319 - E324
  • [59] Mesenchymal stem cells injection in degenerated intervertebral disc: cell leakage may induce osteophyte formation
    Vadala, Gianluca
    Sowa, Gwendolyn
    Hubert, Mark
    Gilbertson, Lars G.
    Denaro, Vincenzo
    Kang, James D.
    [J]. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 2012, 6 (05) : 348 - 355
  • [60] Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010
    Vos, Theo
    Flaxman, Abraham D.
    Naghavi, Mohsen
    Lozano, Rafael
    Michaud, Catherine
    Ezzati, Majid
    Shibuya, Kenji
    Salomon, Joshua A.
    Abdalla, Safa
    Aboyans, Victor
    Abraham, Jerry
    Ackerman, Ilana
    Aggarwal, Rakesh
    Ahn, Stephanie Y.
    Ali, Mohammed K.
    Alvarado, Miriam
    Anderson, H. Ross
    Anderson, Laurie M.
    Andrews, Kathryn G.
    Atkinson, Charles
    Baddour, Larry M.
    Bahalim, Adil N.
    Barker-Collo, Suzanne
    Barrero, Lope H.
    Bartels, David H.
    Basanez, Maria-Gloria
    Baxter, Amanda
    Bell, Michelle L.
    Benjamin, Emelia J.
    Bennett, Derrick
    Bernabe, Eduardo
    Bhalla, Kavi
    Bhandari, Bishal
    Bikbov, Boris
    Bin Abdulhak, Aref
    Birbeck, Gretchen
    Black, James A.
    Blencowe, Hannah
    Blore, Jed D.
    Blyth, Fiona
    Bolliger, Ian
    Bonaventure, Audrey
    Boufous, Soufi Ane
    Bourne, Rupert
    Boussinesq, Michel
    Braithwaite, Tasanee
    Brayne, Carol
    Bridgett, Lisa
    Brooker, Simon
    Brooks, Peter
    [J]. LANCET, 2012, 380 (9859) : 2163 - 2196
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