Cell therapy for intervertebral disc herniation and degenerative disc disease: clinical trials

被引：67

作者：

Schol, Jordy ^{[1
]}

Sakai, Daisuke ^{[1
]}

机构：

[1] Tokai Univ, Sch Med, Dept Orthopaed Surg, 143 Shimokasya, Isehara, Kanagawa 2591143, Japan

来源：

INTERNATIONAL ORTHOPAEDICS | 2019年 / 43卷 / 04期

关键词：

Clinical trials; Cell therapy; Regenerative medicine; Intervertebral disc; Degeneration; MESENCHYMAL STEM-CELLS; BONE-MARROW-CELLS; LOW-BACK-PAIN; CHONDROCYTE TRANSPLANTATION; INTRADISCAL INJECTION; MAGNETIC-RESONANCE; LUMBAR FUSION; STROMAL CELLS; REPAIR; MODEL;

D O I：

10.1007/s00264-018-4223-1

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

Low back pain is the primary cause of disability and is highly associated with progression of intervertebral disc degeneration. Current treatment options are limited and fail to address the origin of the problem. New advancements in cellular therapies might offer novel and potent strategies for low back pain patients. In this review, we summarize and discuss the contemporary status of in-human trials investigating cellular transplantation for treatment of low back pain. We aim to highlight current trends, shortcomings, and hurdles for effective clinical trials and consecutive commercialization.

引用

页码：1011 / 1025

页数：15

共 64 条

[1] Changes in perfusion and diffusion in the endplate regions of degenerating intervertebral discs: a DCE-MRI study [J].

Arpinar, Volkan Emre ;

Rand, Scott D. ;

Klein, Andrew P. ;

Maiman, Dennis J. ;

Muftuler, L. Tugan .

EUROPEAN SPINE JOURNAL, 2015, 24 (11) :2458-2467

[2] Advances in the diagnosis of degenerated lumbar discs and their possible clinical application [J].

Brayda-Bruno, Marco ;

Tibiletti, Marta ;

Ito, Keita ;

Fairbank, Jeremy ;

Galbusera, Fabio ;

Zerbi, Alberto ;

Roberts, Sally ;

Wachtel, Ellen ;

Merkher, Yulia ;

Sivan, Sarit Sara .

EUROPEAN SPINE JOURNAL, 2014, 23 :S315-S323

[3] Critical aspects and challenges for intervertebral disc repair and regeneration-Harnessing advances in tissue engineering [J].

Buckley, Conor T. ;

Hoyland, Judith A. ;

Fujii, Kengo ;

Pandit, Abhay ;

Iatridis, James C. ;

Grad, Sibylle .

JOR SPINE, 2018, 1 (03)

[4] Treatment of lumbar degenerative disc disease-associated radicular pain with culture-expanded autologous mesenchymal stem cells: a pilot study on safety and efficacy [J].

Centeno, Christopher ;

Markle, Jason ;

Dodson, Ehren ;

Stemper, Ian ;

Williams, Christopher J. ;

Hyzy, Matthew ;

Ichim, Thomas ;

Freeman, Michael .

JOURNAL OF TRANSLATIONAL MEDICINE, 2017, 15

[5] Growth differentiation factor 6 and transforming growth factor-beta differentially mediate mesenchymal stem cell differentiation, composition, and micromechanical properties of nucleus pulposus constructs [J].

Clarke, Louis E. ;

McConnell, James C. ;

Sherratt, Michael J. ;

Derby, Brian ;

Richardson, Stephen M. ;

Hoyland, Judith A. .

ARTHRITIS RESEARCH & THERAPY, 2014, 16 (02)

[6] TGF-β1 and GDF5 Act Synergistically to Drive the Differentiation of Human Adipose Stromal Cells toward Nucleus Pulposus-like Cells [J].

Colombier, Pauline ;

Clouet, Johann ;

Boyer, Cecile ;

Ruel, Maeva ;

Bonin, Gaelle ;

Lesoeur, Julie ;

Moreau, Anne ;

Fellah, Borhane-Hakim ;

Weiss, Pierre ;

Lescaudron, Laurent ;

Camus, Anne ;

Guicheux, Jerome .

STEM CELLS, 2016, 34 (03) :653-667

[7] Prospective study of disc repair with allogeneic chondrocytes Presented at the 2012 Joint Spine Section Meeting Clinical article [J].

Coric, Domagoj ;

Pettine, Kenneth ;

Sumich, Andrew ;

Boltes, Margaret O. .

JOURNAL OF NEUROSURGERY-SPINE, 2013, 18 (01) :85-95

[8] Qualitative grading of disc degeneration by magnetic resonance in the lumbar and cervical spine: lack of correlation with histology in surgical cases [J].

Davies, B. M. ;

Atkinson, R. A. ;

Ludwinski, F. ;

Freemont, A. J. ;

Hoyland, J. A. ;

Gnanalingham, K. K. .

BRITISH JOURNAL OF NEUROSURGERY, 2016, 30 (04) :414-421

[9] Spinal-fusion surgery - The case for restraint [J].

Deyo, RA ;

Nachemson, A ;

Mirza, SK .

NEW ENGLAND JOURNAL OF MEDICINE, 2004, 350 (07) :722-726

[10] Intra-discal injection of autologous, hypoxic cultured bone marrow-derived mesenchymal stem cells in five patients with chronic lower back pain: a long-term safety and feasibility study [J].

Elabd, Christian ;

Centeno, Christopher J. ;

Schultz, John R. ;

Lutz, Gregory ;

Ichim, Thomas ;

Silva, Francisco J. .

JOURNAL OF TRANSLATIONAL MEDICINE, 2016, 14

← 1 2 3 4 5 6 7 →