Advances in chemical ligation strategies for the synthesis of glycopeptides and glycoproteins

被引：171
|
作者：
Payne, Richard J. [1 ]
Wong, Chi-Huey [2 ,3 ]
机构：
[1] Univ Sydney, Sch Chem, Sydney, NSW 2006, Australia
[2] Acad Sinica, Taipei 115, Taiwan
[3] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA
来源：
CHEMICAL COMMUNICATIONS | 2010年 / 46卷 / 01期
关键词：
SOLID-PHASE SYNTHESIS; EXPRESSED PROTEIN LIGATION; SUGAR-ASSISTED LIGATION; CYSTEINE-FREE PEPTIDE; SAFETY-CATCH LINKER; POLYPEPTIDE-SYNTHESIS; MUC1; GLYCOPEPTIDES; TYROSINE SULFATE; BUILDING-BLOCKS; P-SELECTIN;
D O I：
10.1039/b913845e
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A number of recent advances in the chemical synthesis of glycopeptides and glycoproteins are described, with particular focus on the development of peptide ligation strategies and their implementation in the convergent assembly of complex glycopeptides. Recent applications in the synthesis of full length homogeneous glycoproteins are also highlighted.
引用
收藏
页码：21 / 43
页数：23
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