IGFBP-2 partly mediates the early metabolic improvements caused by bariatric surgery

被引：28

作者：

Faramia, Justine ^{[1
,2
]}

Hao, Zheng ^{[3
]}

Mumphrey, Michael B. ^{[3
]}

Townsend, R. Leigh ^{[3
]}

Miard, Stephanie ^{[2
]}

Carreau, Anne-Marie ^{[4
]}

Nadeau, Melanie ^{[1
]}

Frisch, Frederique ^{[4
]}

Baraboi, Elena-Dana ^{[1
]}

Grenier-Larouche, Thomas ^{[4
]}

Noll, Christophe ^{[4
]}

Li, Meng ^{[1
,2
]}

Biertho, Laurent ^{[1
]}

Marceau, Simon ^{[1
]}

Hould, Frederic-Simon ^{[1
]}

Lebel, Stefane ^{[1
]}

Morrison, Christopher D. ^{[3
]}

Munzberg, Heike ^{[3
]}

Richard, Denis ^{[2
]}

Carpentier, Andre C. ^{[4
]}

Tchernof, Andre ^{[1
]}

Berthoud, Hans-Rudolf ^{[3
]}

Picard, Frederic ^{[1
,2
]}

机构：

[1] Univ Laval, Ctr Rech Inst Univ Cardiol & Pneumol Quebec, Quebec City, PQ, Canada

[2] Univ Laval, Fac Pharm, Quebec City, PQ, Canada

[3] Louisiana State Univ Syst, Pennington Biomed Res Ctr, Neurobiol Nutr & Metab Dept, Baton Rouge, LA 70808 USA

[4] Univ Sherbrooke, Ctr Rech CHUS, Dept Med, Div Endocrinol, Sherbrooke, PQ, Canada

来源：

CELL REPORTS MEDICINE | 2021年 / 2卷 / 04期

基金：

加拿大健康研究院; 美国国家卫生研究院;

关键词：

FACTOR-BINDING PROTEIN-2; GASTRIC BYPASS-SURGERY; CARDIOVASCULAR RISK-FACTORS; BILIOPANCREATIC DIVERSION; WEIGHT-LOSS; GLUCOSE-HOMEOSTASIS; SLEEVE GASTRECTOMY; MOUSE MODELS; BODY-WEIGHT; BILE-ACIDS;

D O I：

10.1016/j.xcrm.2021.100248

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Insulin-like growth factor-binding protein (IGFBP)-2 is a circulating biomarker of cardiometabolic health. Here, we report that circulating IGFBP-2 concentrations robustly increase after different bariatric procedures in humans, reaching higher levels after biliopancreatic diversion with duodenal switch (BPD-DS) than after Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG). This increase is closely associated with insulin sensitization. In mice and rats, BPD-DS and RYGB operations also increase circulating IGFBP-2 levels, which are not affected by SG or caloric restriction. In mice, Igfbp2 deficiency significantly impairs surgery-induced loss in adiposity and early improvement in insulin sensitivity but does not affect long-term enhancement in glucose homeostasis. This study demonstrates that the modulation of circulating IGFBP-2 may play a role in the early improvement of insulin sensitivity and loss of adiposity brought about by bariatric surgery.

引用

页数：16

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