An efficient synthesis of 2,3-dihydro-1H-pyrimido[1,2-a]quinoxaline 6-oxides

被引：0
|
作者：
García, MB [1 ]
Orelli, LR [1 ]
Magri, ML [1 ]
Perillo, IA [1 ]
机构：
[1] Fac Farm & Bioquim, Dept Quim Organ, RA-1113 Buenos Aires, DF, Argentina
来源：
SYNTHESIS-STUTTGART | 2002年 / 18期
关键词：
heterocycles; nitrogen; cyclizations; antibiotics; antitumor agents;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
5-Substituted 2,3-dihydro-1H-pyrimido[1,2-a]quinoxaline 6-oxides 1a-f were synthesized by ring closure of N-acyl-N'-(o-nitroaryl)-1,3-propanediamines 2 with ethyl polyphosphate (PPE) or trimethylsilyl polyphosphate (PPSE) to the corresponding 2-substituted 1-(o-nitroaryl)-1,4,5,6-tetrahydropyrimidines 3, followed by spontaneous heterocyclization. The method was extended to the synthesis of the homologous 6-aryl-1,2,3,4-tetrahydro-1,3-diazepino[1,2-a]quinoxaline 7-oxide (1g).
引用
收藏
页码：2687 / 2690
页数：4
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