An efficient synthesis of 2,3-dihydro-1H-pyrimido[1,2-a]quinoxaline 6-oxides

被引：0

作者：

García, MB ^{[1
]}

Orelli, LR ^{[1
]}

Magri, ML ^{[1
]}

Perillo, IA ^{[1
]}

机构：

[1] Fac Farm & Bioquim, Dept Quim Organ, RA-1113 Buenos Aires, DF, Argentina

来源：

SYNTHESIS-STUTTGART | 2002年 / 18期

关键词：

heterocycles; nitrogen; cyclizations; antibiotics; antitumor agents;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

5-Substituted 2,3-dihydro-1H-pyrimido[1,2-a]quinoxaline 6-oxides 1a-f were synthesized by ring closure of N-acyl-N'-(o-nitroaryl)-1,3-propanediamines 2 with ethyl polyphosphate (PPE) or trimethylsilyl polyphosphate (PPSE) to the corresponding 2-substituted 1-(o-nitroaryl)-1,4,5,6-tetrahydropyrimidines 3, followed by spontaneous heterocyclization. The method was extended to the synthesis of the homologous 6-aryl-1,2,3,4-tetrahydro-1,3-diazepino[1,2-a]quinoxaline 7-oxide (1g).

引用

页码：2687 / 2690

页数：4

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