Synthesis of vinca alkaloids and related compounds -: part 94 [1].: Epimerization of compounds with aspidospermane and D-secoaspidospermane skeleton

被引:11
作者
Kalaus, G
Juhász, I
Éles, J
Greiner, I
Kajtár-Peredy, M
Brlik, J
Szabó, L
Szántay, C
机构
[1] Tech Univ Budapest, Dept Organ Chem, H-1521 Budapest, Hungary
[2] Gedeon Richter Ltd, Chem Works, H-1103 Budapest, Hungary
[3] Hungarian Acad Sci, Chem Res Ctr, Inst Chem, H-1525 Budapest, Hungary
关键词
D O I
10.1002/jhet.5570370205
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The individual epimerization steps of vincadifformine (1), deethylvincadifformine isomers (2,3), their synthetic intermediates (4-13) as well as that of simpler compounds with D-secoaspidospermane skeleton (15-17) were studied a) in protic medium (boiling deuteroacetic acidic) and b) under reductive (with sodium borodeuteride in boiling acetic acid, or with sodium borohydride in boiling deuteroacetic acid) conditions.
引用
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页码:245 / 251
页数:7
相关论文
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