α-Bulnesene, a PAF inhibitor isolated from the essential oil of Pogostemon cablin

被引：33

作者：

Tsai, Ying-Chieh ^{[1
]}

Hsu, Hui-Chun

Yang, Wen-Chia

Tsai, Wei-Jern

Chen, Chien-Chih

Watanabe, Takashi

机构：

[1] Natl Yang Ming Univ, Inst Biochem & Mol Biol, Taipei 112, Taiwan

[2] Yangsen Biotechnol Co Ltd, Taipei, Taiwan

[3] Natl Res Inst Chinese Med, Taipei, Taiwan

来源：

FITOTERAPIA | 2007年 / 78卷 / 01期

关键词：

essential oil; Pogostemon cablin; platelet-activating factor (PAF);

D O I：

10.1016/j.fitote.2006.09.016

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Steam distilled essential oil from the aerial parts of Pogostemon cablin was analyzed by gas chromatography-mass spectrometry (GC-MS). Forty one compounds were identified of which alpha-guaiene (20.62%) and alpha-bulnesene (16.18%) were major constituents. Furthermore, fractionation of the essential oil from P cablin guided by inhibitory activity against PAF-induced platelet aggregation led to the isolation of the sesquiterpene, alpha-bulnesene. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：7 / 11

页数：5

共 18 条

[1]

Feng Y, 1999, Zhong Yao Cai, V22, P241

[2]

Hsiao G, 1998, BIOL PHARM BULL, V21, P688, DOI 10.1248/bpb.21.688

[3]

ITOKAWA H, 1981, CHEM PHARM BULL, V29, P254

[4] Magnone A and B, novel anti-PAF tetrahydrofuran lignans from the flower buds of Magnolia fargesii [J].

Jung, KY ;

Kim, DS ;

Oh, SR ;

Park, SH ;

Lee, IS ;

Lee, JJ ;

Shin, DH ;

Lee, HK .

JOURNAL OF NATURAL PRODUCTS, 1998, 61 (06) :808-811

[5] Antiplatelet effect of marchantinquinone, isolated from Reboulia hemisphaerica, in rabbit washed platelets [J].

Liao, CH ;

Ko, FN ;

Wu, CL ;

Teng, CM .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 2000, 52 (03) :353-359

[6] Bakkenolide G, a natural PAF-receptor antagonist [J].

Liao, CH ;

Ko, FN ;

Wu, TS ;

Teng, CM .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 1997, 49 (12) :1248-1253

[7]

Luo Jipeng, 2002, Zhong Yao Cai, V25, P21

[8] Antimutagenic activity of flavonoids from Pogostemon cablin [J].

Miyazawa, M ;

Okuno, Y ;

Nakamura, S ;

Kosaka, H .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2000, 48 (03) :642-647

[9] PURIFICATION AND CHARACTERIZATION OF THE SESQUITERPENE CYCLASE PATCHOULOL SYNTHASE FROM POGOSTEMON-CABLIN [J].

MUNCK, SL ;

CROTEAU, R .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1990, 282 (01) :58-64

[10]

Pacciaroni AD, 2000, PLANTA MED, V66, P720, DOI 10.1055/s-2000-9600

← 1 2 →