Strategies and Challenges to Myocardial Replacement Therapy

被引：33

作者：

Feric, Nicole T. ^{[1
]}

Radisic, Milica ^{[1
,2
,3
]}

机构：

[1] Univ Toronto, Univ Hlth Network, Inst Biomat & Biomed Engn, Toronto, ON M5S 3G9, Canada

[2] Univ Toronto, Univ Hlth Network, Dept Chem Engn & Appl Chem, Toronto, ON M5S 3G9, Canada

[3] Univ Toronto, Univ Hlth Network, Toronto Gen Res Inst, Toronto, ON M5S 3G9, Canada

来源：

STEM CELLS TRANSLATIONAL MEDICINE | 2016年 / 5卷 / 04期

基金：

加拿大自然科学与工程研究理事会; 美国国家卫生研究院; 加拿大健康研究院;

关键词：

CELL-DERIVED CARDIOMYOCYTES; EMBRYONIC STEM-CELLS; CARDIAC PROGENITOR CELLS; HEART-FAILURE; HUMAN FIBROBLASTS; ISCHEMIC-HEART; DIFFERENTIATION; MATURATION; MOUSE; REGENERATION;

D O I：

10.5966/sctm.2015-0288

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Cardiovascular diseases account for the majority of deaths globally and are a significant drain on economic resources. Although heart transplants and left-ventricle assist devices are the solution for some, the best chance for many patients who suffer because of a myocardial infarction, heart failure, or a congenital heart disease may be cell-based regenerative therapies. Such therapies can be divided into two categories: the application of a cell suspension and the implantation of an in vitro engineered tissue construct to the damaged area of the heart. Both strategies have their advantages and challenges, and in this review, we discuss the current state of the art in myocardial regeneration, the challenges to success, and the future direction of the field.

引用

页码：410 / 416

页数：7

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