Pancreatic cancer stroma: controversies and current insights

被引:36
|
作者
Ansari, Daniel
Carvajo, Maria
Bauden, Monika
Andersson, Roland
机构
[1] Lund Univ, Dept Surg, Clin Sci Lund, Lund, Sweden
[2] Skane Univ Hosp, Lund, Sweden
关键词
Pancreatic cancer; stroma; desmoplasia; microenvironment; targeted therapy; NERVE GROWTH-FACTOR; STELLATE CELLS; DUCTAL ADENOCARCINOMA; TUMOR PROGRESSION; SONIC HEDGEHOG; THERAPEUTIC APPROACH; PERINEURAL INVASION; GENOMIC ANALYSES; NAB-PACLITAXEL; T-CELLS;
D O I
10.1080/00365521.2017.1293726
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Pancreatic cancer is characterized by a dense stromal response. The stroma includes a heterogeneous mass of cells, including pancreatic stellate cells, fibroblasts, immune cells and nerve cells, as well as extracellular matrix proteins, cytokines and growth factors, which interact with the tumor cells. Previous research has indicated that stromal elements contribute to tumor growth and aggressiveness. However, recent studies suggest that some elements of the stroma may actually restrain the tumor. This review focuses on the complex interactions between the stromal microenvironment and tumor cells, discussing molecular mechanisms and potential future diagnostic and therapeutic approaches by targeting the stroma.
引用
收藏
页码:641 / 646
页数:6
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