Brain iron homeostasis, the choroid plexus, and localization of iron transport proteins

被引:100
作者
Rouault, Tracey A. [1 ]
Zhang, De-Liang [1 ]
Jeong, Suh Young [1 ]
机构
[1] NICHHD, Program Mol Med, NIH, Bethesda, MD 20892 USA
关键词
Choroid plexus; Iron transport; Blood brain barrier; Blood-CSF barrier; Ferroportin; Ceruloplasmin; BARRIER; METABOLISM; RAT; CERULOPLASMIN; INVOLVEMENT; DEFICIENCY; ABSORPTION; DISEASE; CELLS; MICE;
D O I
10.1007/s11011-009-9169-y
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Maintenance of appropriate iron homeostasis in the brain is important, but the mechanisms involved in brain iron uptake are incompletely understood. Here, we have analyzed where messenger RNAs that encode iron transport proteins are expressed in the brain, using the Allen Brain atlas, and we conclude that several important iron transporters are highly expressed in the choroid plexus. Based on recent estimates of the surface area of the choroid plexus and on MRI imaging studies of manganese uptake in the brain, we propose that the choroid plexus may have a much greater role than has been previously appreciated in brain iron transport.
引用
收藏
页码:673 / 684
页数:12
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