Metalloantibiotics: Synthesis, characterization and antimicrobial evaluation of bismuth-fluoroquinolone complexes against Helicobacter pylori

被引：35

作者：

Shaikh, Anwar R. ^{[1
]}

Giridhar, Rajani ^{[1
]}

Megraud, Francis ^{[2
,3
]}

Yadav, Mange Ram ^{[1
]}

机构：

[1] Maharaja Sayajirao Univ Baroda, Dept Pharm, Fac Engn & Technol, Vadodara 390001, India

[2] Univ Bordeaux 2, Bacteriol Lab, F-33076 Bordeaux, France

[3] Hop Pellegrin, F-33076 Bordeaux, France

来源：

ACTA PHARMACEUTICA | 2009年 / 59卷 / 03期

关键词：

fluoroquinolone; bismuth; complex; antimicrobial activity; Helicobacter pylori; CRYSTAL-STRUCTURE; METAL-BINDING; CIPROFLOXACIN; PROTEIN;

D O I：

10.2478/v10007-009-0027-6

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Novel organometallic compounds have been prepared by complexing the fluoroquinolones, norfloxacin, ofloxacin, ciprofloxacin, sparfloxacin, lomefloxacin, pefloxacin and gatifloxacin, with bismuth. The complexes were characterized by UV, IR, atomic absorption spectroscopy, elemental analysis, differential scanning calorimetry, thermogravimetric analysis and mass spectrometry. Their antibacterial potential against Helicobacter pylori and other microorganisms was investigated. These compounds were found to possess strong activity against Helicobacter pylori with a minimum inhibitory concentration of 0.5 mg L-1. They also exhibited moderate activity against Escherichia coli, Staphylococcus aureus, Bacillus pumilus and Staphylococcus epidermidis. These bismuth-fluoroquinolone complexes have the potential to be developed as drugs against H. pylori related ailments.

引用

页码：259 / 271

页数：13

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