Coding triplets in the tRNA acceptor-TψC arm and their role in present and past tRNA recognition

被引：5

作者：

Agmon, Ilana ^{[1
,2
]}

Fayerverker, Itay ^{[3
]}

Mor, Tal ^{[3
]}

机构：

[1] Technion Israel Inst Technol, Schulich Fac Chem, Inst Adv Studies Theoret Chem, IL-3200003 Haifa, Israel

[2] Hebrew Univ Jerusalem, Fritz Haber Res Ctr Mol Dynam, Jerusalem, Israel

[3] Technion, Dept Comp Sci, Haifa, Israel

来源：

FEBS LETTERS | 2021年 / 595卷 / 07期

关键词：

aminoacylation; genetic code; origin of life; synthetase; translation; tRNA; AMINOACYL-TRANSFER-RNA; CRYSTAL-STRUCTURE; TERNARY COMPLEX; GENETIC-CODE; SYNTHETASE; SEQUENCE; IDENTITY; REVEALS; DETERMINANTS; COMPILATION;

D O I：

10.1002/1873-3468.14044

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The mechanism and evolution of the recognition scheme between key components of the translation system, that is, tRNAs, synthetases, and elongation factors, are fundamental issues in understanding the translation of genetic information into proteins. Statistical analysis of bacterial tRNA sequences reveals that for six amino acids, a string of 10 nucleotides preceding the tRNA 3' end carries cognate coding triplets to nearly full extent. The triplets conserved in positions 63-67 are implicated in the recognition by the elongation factor EF-Tu, and those conserved in positions 68-72, in the identification of cognate tRNAs, and their derived minihelices by class IIa synthetases. These coding triplets are suggested to have primordial origin, being engaged in aminoacylation of prebiotic tRNAs and in the establishment of the canonical codon set.

引用

页码：913 / 924

页数：12

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