Acylated Oleanane-Type Triterpene Saponins with Acceleration of Gastrointestinal Transit and Inhibitory Effect on Pancreatic Lipase from Flower Buds of Chinese Tea Plant (Camellia sinensis)

被引：59

作者：

Yoshikawa, Masayuki ^{[1
]}

Sugimoto, Sachiko ^{[1
]}

Kato, Yasuyo ^{[1
]}

Nakamura, Seikou ^{[1
]}

Wang, Tao ^{[1
]}

Yamashita, Chihiro ^{[1
]}

Matsuda, Hisashi ^{[1
]}

机构：

[1] Kyoto Pharmaceut Univ, Yamashina Ku, Kyoto 6078412, Japan

来源：

CHEMISTRY & BIODIVERSITY | 2009年 / 6卷 / 06期

关键词：

BIOACTIVE SAPONINS; MEDICINAL FLOWERS; PANAX-GINSENG; FLAVONOL GLYCOSIDES; SRI-LANKA; SEEDS; OLIGOGLYCOSIDES; L; FLORATHEASAPONINS; ASSAMSAPONINS;

D O I：

10.1002/cbdv.200800153

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The MeOH extract and its BuOH-soluble fraction (crude saponin fraction) from the flower buds of chinese tea plant (Camellia sinensis (L.) O. KUNTZE; Fujian Province) were found to exhibit accelerating effects on gastrointestinal transit in mice and inhibitory effects against pancreatic lipase. From the BuOH-soluble fraction, three new acylated oleanane-type triterpene oligoglycosides, chakasaponins I, II, and III (1-3, resp), were isolated together with 13 known compound. The chemical structures 1-3 were elucidated on the basis of chemical and physicochemical evidence. Compounds 1-3 showed accelerating effects on gastrointestinal transit in mice and inhibitory effects against porcine pancreatic lipase (IC50 = 150 -530 mu M).

引用

页码：903 / 915

页数：13

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