The glucagon-like peptide 1 receptor agonist liraglutide attenuates the reinforcing properties of alcohol in rodents

被引：92

作者：

Vallof, Daniel ^{[1
]}

Maccioni, Paola ^{[2
]}

Colombo, Giancarlo ^{[2
]}

Mandrapa, Minja ^{[1
]}

Jornulf, Julia Winsa ^{[1
]}

Egecioglu, Emil ^{[3
]}

Engel, Jorgen A. ^{[1
]}

Jerlhag, Elisabet ^{[1
]}

机构：

[1] Univ Gothenburg, Sahlgrenska Acad, Dept Pharmacol, Inst Neurosci & Physiol, Medicinaregatan 13A, SE-40530 Gothenburg, Sweden

[2] Natl Res Council Italy, Sect Cagliari, Inst Neurosci, Cagliari, Italy

[3] Lund Univ, Sect Diabet & Metab, Inst Expt Med Sci, S-22100 Lund, Sweden

来源：

ADDICTION BIOLOGY | 2016年 / 21卷 / 02期

基金：

瑞典研究理事会;

关键词：

Addictive behaviours; dependence; reward; VENTRAL TEGMENTAL AREA; FOOD-INTAKE; NUCLEUS-ACCUMBENS; BODY-WEIGHT; ETHANOL-CONSUMPTION; INTERMITTENT ACCESS; PROMOTES SATIETY; GLP-1; ANALOG; EXENDIN-4; DOPAMINE;

D O I：

10.1111/adb.12295

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The incretin hormone, glucagon-like peptide 1 (GLP-1), regulates gastric emptying, glucose-dependent stimulation of insulin secretion and glucagon release, and GLP-1 analogs are therefore approved for treatment of type II diabetes. GLP-1 receptors are expressed in reward-related areas such as the ventral tegmental area and nucleus accumbens, and GLP-1 was recently shown to regulate several alcohol-mediated behaviors as well as amphetamine-induced, cocaine-induced and nicotine-induced reward. The present series of experiments were undertaken to investigate the effect of the GLP-1 receptor agonist, liraglutide, on several alcohol-related behaviors in rats that model different aspects of alcohol use disorder in humans. Acute liraglutide treatment suppressed the well-documented effects of alcohol on the mesolimbic dopamine system, namely alcohol-induced accumbal dopamine release and conditioned place preference in mice. In addition, acute administration of liraglutide prevented the alcohol deprivation effect and reduced alcohol intake in outbred rats, while repeated treatment of liraglutide decreased alcohol intake in outbred rats as well as reduced operant self-administration of alcohol in selectively bred Sardinian alcohol-preferring rats. Collectively, these data suggest that GLP-1 receptor agonists could be tested for treatment of alcohol dependence in humans.

引用

页码：422 / 437

页数：16

共 68 条

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