Evaluation of the anti-inflammatory efficacy of Lotus corniculatus

被引：22

作者：

Koelzer, Janaina ^{[1
]}

Pereira, Diana Ana ^{[1
]}

Dalmarco, Juliana Bastos ^{[2
]}

Pizzolatti, Moacir Geraldo ^{[2
]}

Frode, Tania Silvia ^{[1
]}

机构：

[1] Univ Fed Santa Catarina, Ctr Hlth Sci, Dept Clin Anal, BR-88040970 Florianopolis, SC, Brazil

[2] Univ Fed Santa Catarina, Ctr Phys & Math Sci, Dept Chem, BR-88040970 Florianopolis, SC, Brazil

来源：

FOOD CHEMISTRY | 2009年 / 117卷 / 03期

关键词：

Lotus corniculatus; Anti-inflammatory activity; Pleurisy; Mediators of inflammation; Mice; OLEANOLIC ACID; TRITERPENOID SAPONINS; CONDENSED TANNINS; PROANTHOCYANIDINS; INHIBITION; MODEL;

D O I：

10.1016/j.foodchem.2009.04.044

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The anti-inflammatory effects of the crude extract (CE) of Lotus corniculatus var. Sao Gabriel and its derived hexane (HEX), ethyl acetate (AcOEt), n-butanol (BuOH) and aqueous (Aq) fractions and isolated compounds kaempferitrin, oleanolic acid and beta-sitosterol, in a mouse model of pleurisy induced by carrageenan were investigated. Swiss mice were used in the in vivo experiments. The crude extract of L corniculatus and its derived fractions, and also its isolated compounds, inhibited leukocytes, exudation, and myeloperoxidase (MPO) and adenosine-deaminase (ADA) activities, as well as nitrite/nitrate concentration and interleukin-1 beta (IL-1 beta) level (p < 0.05). L. corniculatus showed important anti-inflammatory activity by inhibition not only of leukocytes and/or exudation, but also of pro-inflammatory enzymes and mediators such as MPO, ADA, and IL-1 beta. The constituent's kaempferitrin, oleanolic acid and beta-sitosterol may well account for it. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：444 / 450

页数：7

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