Regulation of bone mass in inflammatory diseases

被引：24
作者：
Adami, Giovanni [1 ]
机构：
[1] Univ Verona, Rheumatol Unit, Pz Scuro 10, I-37134 Verona, Italy
来源：
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM | 2022年 / 36卷 / 02期
关键词：
inflammation; wnt system; osteoporosis; bone metabolism; disease modifying drugs; glucocorticoids; TNF-ALPHA THERAPY; MINERAL DENSITY; RHEUMATOID-ARTHRITIS; VERTEBRAL FRACTURES; LUMBAR SPINE; METABOLISM; INFLIXIMAB; RISK; OSTEOPOROSIS; BISPHOSPHONATES;
D O I：
10.1016/j.beem.2021.101611
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Inflammation is among the major determinants of bone loss in chronic disease and aging. Bone metabolism is radically affected by inflammation with consequent bone loss and increased fracture risk. Various cytokines and mediators are involved in the pathogenesis of bone loss in inflammatory conditions. The present review has the aim of discussing the main pathways involved in the pathogenesis of bone loss in inflammatory diseases, focusing in particular on the Wnt system and its regulators. Literature review of studies published between inception to 2021 on osteoporosis and inflammation was conducted. I will discuss the epidemiology of osteoporosis and fractures in common inflammatory diseases. The molecular basis of bone loss related to inflammation will be discussed as well. Finally, the effects of various anti-inflammatory medications on bone metabolism will be reviewed.(c) 2021 Elsevier Ltd. All rights reserved.
引用
收藏
页数：9
相关论文
共 81 条
[1]   JAK inhibition increases bone mass in steady-state conditions and ameliorates pathological bone loss by stimulating osteoblast function [J].
Adam, Susanne ;
Simon, Nils ;
Steffen, Ulrike ;
Andes, Fabian T. ;
Scholtysek, Carina ;
Mueller, Dorothea I. H. ;
Weidner, Daniela ;
Andreev, Darja ;
Kleyer, Arnd ;
Culemann, Stephan ;
Hahn, Madelaine ;
Schett, Georg ;
Kroenke, Gerhard ;
Frey, Silke ;
Hueber, Axel J. .
SCIENCE TRANSLATIONAL MEDICINE, 2020, 12 (530)
[2]   Association between exposure to fine particulate matter and osteoporosis: a population-based cohort study [J].
Adami, G. ;
Cattani, G. ;
Rossini, M. ;
Viapiana, O. ;
Olivi, P. ;
Orsolini, G. ;
Bertoldo, E. ;
Fracassi, E. ;
Gatti, D. ;
Fassio, A. .
OSTEOPOROSIS INTERNATIONAL, 2022, 33 (01) :169-176
[3]   Glucocorticoid-induced osteoporosis: 2019 concise clinical review [J].
Adami, G. ;
Saag, K. G. .
OSTEOPOROSIS INTERNATIONAL, 2019, 30 (06) :1145-1156
[4]   Osteoporosis in Rheumatic Diseases [J].
Adami, Giovanni ;
Fassio, Angelo ;
Rossini, Maurizio ;
Caimmi, Cristian ;
Giollo, Alessandro ;
Orsolini, Giovanni ;
Viapiana, Ombretta ;
Gatti, Davide .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2019, 20 (23)
[5]   Osteoporosis Pathophysiology, Epidemiology, and Screening in Rheumatoid Arthritis [J].
Adami, Giovanni ;
Saag, Kenneth G. .
CURRENT RHEUMATOLOGY REPORTS, 2019, 21 (07)
[6]   New insights on the role, pathogenesis, and treatment of osteoporosis and bone erosions in rheumatoid arthritis [J].
Adami, Giovanni ;
Viapiana, Ombretta ;
Rossini, Maurizio ;
Fassio, Angelo ;
Orsolini, Giovanni ;
Idolazzi, Luca ;
Gatti, Davide .
CLINICAL CASES IN MINERAL AND BONE METABOLISM, 2018, 15 (02) :177-182
[7]   Effects of TNF Inhibitors on Parathyroid Hormone and Wnt Signaling Antagonists in Rheumatoid Arthritis [J].
Adami, Giovanni ;
Orsolini, Giovanni ;
Adami, Silvano ;
Viapiana, Ombretta ;
Idolazzi, Luca ;
Gatti, Davide ;
Rossini, Maurizio .
CALCIFIED TISSUE INTERNATIONAL, 2016, 99 (04) :360-364
[8]   COPD as an independent risk factor for osteoporosis and fractures [J].
Adas-Okuma, M. G. ;
Maeda, S. S. ;
Gazzotti, M. R. ;
Roco, C. M. ;
Pradella, C. O. ;
Nascimento, O. A. ;
Porto, E. F. ;
Vieira, J. G. H. ;
Jardim, J. R. ;
Lazaretti-Castro, M. .
OSTEOPOROSIS INTERNATIONAL, 2020, 31 (04) :687-697
[9]   The Impact of Conventional and Biological Disease Modifying Antirheumatic Drugs on Bone Biology. Rheumatoid Arthritis as a Case Study [J].
Barreira, Sofia Carvalho ;
Fonseca, Joao Eurico .
CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY, 2016, 51 (01) :100-109
[10]   Inhibition of antigen presentation and T cell costimulation blocks PTH-induced bone loss [J].
Bedi, Brahmchetna ;
Li, Jau-Yi ;
Grassi, Francesco ;
Tawfeek, Hesham ;
Weitzmann, M. Neale ;
Pacifici, Roberto .
SKELETAL BIOLOGY AND MEDICINE, 2010, 1192 :215-221
123456789