Abnormal Brain Lateralization and Connectivity in Schizophrenia

被引：5
作者：
Ribolsi, Michele [2 ]
Koch, Giacomo [1 ,3 ]
Magni, Valentina [2 ]
Di Lorenzo, Giorgio [2 ]
Rubino, Ivo Alex [2 ]
Siracusano, Alberto [2 ]
Centonze, Diego [1 ,3 ]
机构：
[1] Univ Roma Tor Vergata, Neurol Clin, Dipartimento Neurosci, I-00133 Rome, Italy
[2] Univ Roma Tor Vergata, Clin Psichiatr, Dipartimento Neurosci, I-00133 Rome, Italy
[3] Fdn Santa Lucia, CERC, Rome, Italy
来源：
REVIEWS IN THE NEUROSCIENCES | 2009年 / 20卷 / 01期
关键词：
brain asymmetry; cerebral cortex; psychosis; synaptic plasticity; transcranial magnetic stimulation; P300; TRANSCRANIAL MAGNETIC STIMULATION; RESOLUTION ELECTROMAGNETIC TOMOGRAPHY; ALTERED HEMISPHERIC-ASYMMETRY; AUDITORY MISMATCH NEGATIVITY; WHITE-MATTER ABNORMALITIES; EVENT-RELATED POTENTIALS; SUPERIOR TEMPORAL GYRUS; CEREBRAL ASYMMETRY; PLANUM TEMPORALE; CORPUS-CALLOSUM;
D O I：
暂无
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Schizophrenia is a complex disorder mainly characterized by thought disturbances, hallucinations, and decay of social and cognitive performances. From past attempts to identify, the exclusive brain lesions responsible for specific domains of schizophrenia symptoms such as delusion and auditory hallucinations, recent data pointed towards network alterations leading to abnormal brain asymmetry and connectivity as important determinants of schizophrenia pathophysiology. Several contributions have reported reduced brain lateralization in schizophrenia, causing a failure of left hemisphere dominance. Evidence of altered connectivity, among distinct cortical areas is also accumulating. The aim of the present article is to critically review such contributions.
引用
收藏
页码：61 / 70
页数：10
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