Helicobacter pylori and gastroesophageal reflux disease: a review of this intriguing relationship

被引：26

作者：

Almada de Souza, R. Canzi ^{[1
]}

Cavalcante Lima, Jose Hermenio ^{[2
]}

机构：

[1] Univ Fed Parana, Dept Clin Med, Div Gastroenterol, BR-80030200 Curitiba, Parana, Brazil

[2] Univ Fed Parana, Dept Clin Pathol, BR-80030200 Curitiba, Parana, Brazil

来源：

DISEASES OF THE ESOPHAGUS | 2009年 / 22卷 / 03期

关键词：

gastroesophageal reflux; helicobacter infection; helicobacter pylori; immunology; REGULATORY T-CELLS; NF-KAPPA-B; GASTRIC-CANCER; ATROPHIC GASTRITIS; BARRETTS-ESOPHAGUS; CORPUS GASTRITIS; MONGOLIAN GERBILS; EPITHELIAL-CELLS; ACID-SECRETION; DUODENAL-ULCER;

D O I：

10.1111/j.1442-2050.2008.00911.x

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

A possible association between gastroesophageal reflux disease (GERD) and Helicobacter pylori (H. pylori) infection has been the subject of study and debate in recent years. This review discusses the pathophysiological and immunological mechanisms implicated in this relationship. Although gastric secretion in the majority of H. pylori-infected individuals is unaltered, this review considers how the bacteria may interfere with gastric acid production and what role it may play in GERD. We also identify the epidemiological evidence that confirms that GERD develops after the infection has been eradicated. Lastly, we clarify how the host's immune response and bacterial virulence factors interfere with this relationship, explaining the highly conflicting results in the literature.

引用

页码：256 / 263

页数：8

共 50 条

[31] Helicobacter pylori infection and gastroesophageal reflux in asthmatic children [J].

Asilsoy, Suna ;

Babayigit, Arzu ;

Olmez, Duygu ;

Uzuner, Nevin ;

Karaman, Ozkan ;

Oren, Oguz ;

Turgut, Canan Sule ;

Tezcan, Dilek .

JOURNAL OF TROPICAL PEDIATRICS, 2008, 54 (02) :129-132

[32] Laryngopharyngeal reflux finding scores correlate with gastroesophageal reflux disease and Helicobacter pylori expression [J].

Tezer, Mesut Sabri ;

Kockar, M. Cem ;

Kockar, Olga ;

Celik, Alper .

ACTA OTO-LARYNGOLOGICA, 2006, 126 (09) :958-961

[33] Gastroesophageal reflux disease in an area with low Helicobacter pylori infection prevalence [J].

Miftahussurur, Muhammad ;

Doohan, Dalla ;

Nusi, Iswan Abbas ;

Adi, Pangestu ;

Rezkitha, Yudith Annisa Ayu ;

Waskito, Langgeng Agung ;

Fauzia, Kartika Afrida ;

Bramantoro, Taufan ;

Maimunah, Ummi ;

Thamrin, Husin ;

Masithah, Safitri Indah ;

Sukadiono, Sukadiono ;

Uchida, Tomohisa ;

Lusida, Maria Inge ;

Yamaoka, Yoshio .

PLOS ONE, 2018, 13 (11)

[34] Analysis of gastric microbiota and Helicobacter pylori infection in gastroesophageal reflux disease [J].

Titong Sugihartono ;

Kartika Afrida Fauzia ;

Muhammad Miftahussurur ;

Langgeng Agung Waskito ;

Purwo Sri Rejeki ;

Reny I’tishom ;

Ricky Indra Alfaray ;

Dalla Doohan ;

Rizki Amalia ;

Camilia Metadea Aji Savitri ;

Yudith Annisa Ayu Rezkitha ;

Junko Akada ;

Takashi Matsumoto ;

Yoshio Yamaoka .

Gut Pathogens, 14

[35] Analysis of gastric microbiota and Helicobacter pylori infection in gastroesophageal reflux disease [J].

Sugihartono, Titong ;

Fauzia, Kartika Afrida ;

Miftahussurur, Muhammad ;

Waskito, Langgeng Agung ;

Rejeki, Purwo Sri ;

I'tishom, Reny ;

Alfaray, Ricky Indra ;

Doohan, Dalla ;

Amalia, Rizki ;

Savitri, Camilia Metadea Aji ;

Rezkitha, Yudith Annisa Ayu ;

Akada, Junko ;

Matsumoto, Takashi ;

Yamaoka, Yoshio .

GUT PATHOGENS, 2022, 14 (01)

[36] Intestinal metaplasia at the gastroesophageal junction is associated with gastroesophageal reflux but not with Helicobacter pylori infection [J].

Hall, Mats ;

Wenner, Jorgen ;

Scherman, Peter ;

Oberg, Stefan .

SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 2018, 53 (10-11) :1179-1185

[37] Meta-analysis of the effectiveness of esomeprazole in gastroesophageal reflux disease and Helicobacter pylori infection [J].

Teng, M. ;

Khoo, A. L. ;

Zhao, Y. J. ;

Lin, L. ;

Lim, B. P. ;

Wu, T. S. ;

Dan, Y. Y. .

JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS, 2015, 40 (04) :368-375

[38] Does a relationship still exist between gastroesophageal reflux and Helicobacter pylori in patients with reflux symptoms? [J].

Michele Grande ;

Giorgio Lisi ;

Flavio De Sanctis ;

Simona Grande ;

Alessia Esser ;

Michela Campanelli ;

Valerio Balassone ;

Giovanni Milito ;

Massimo Villa .

World Journal of Surgical Oncology, 12

[39] The role of interleukin-1 gene polymorphisms and Helicobacter pylori in gastroesophageal reflux disease [J].

Akcil, Gulhan ;

Dogan, Ibrahim ;

Cengiz, Mustafa ;

Engin, Evren Doruk ;

Dogan, Mehmet ;

Unal, Selahattin ;

Cirak, Meltem Yalinay ;

Dursun, Ayse .

TURKISH JOURNAL OF GASTROENTEROLOGY, 2014, 25 :81-85

[40] The relationship between Helicobacter pylori infection and reflux esophagitis and the long-term effects of eradication of Helicobacter pylori on reflux esophagitis [J].

Hojo, Mariko ;

Ueda, Kumiko ;

Takeda, Tsutomu ;

Akazawa, Yoichi ;

Ueyama, Hiroya ;

Shimada, Yuji ;

Asaoka, Daisuke ;

Nagahara, Akihito .

THERAPEUTIC ADVANCES IN GASTROENTEROLOGY, 2021, 14

← 1 2 3 4 5 →