Clinical Chemistry Reference Intervals for C57BL/6J, C57BL/6N, and C3HeB/FeJ Mice (Mus musculus)

被引：0

作者：

Otto, Gordon P. ^{[1
,2
,3
]}

Rathkolb, Birgit ^{[3
,4
,5
]}

Oestereicher, Manuela A. ^{[3
]}

Lengger, Christoph J. ^{[3
]}

Moerth, Corinna ^{[3
,4
]}

Micklich, Kateryna ^{[3
,4
]}

Fuchs, Helmut ^{[3
]}

Gailus-Durner, Valerie ^{[3
]}

Wolf, Eckhard ^{[4
]}

de Angelis, Martin Hrabe ^{[3
,5
,6
]}

机构：

[1] Jena Univ Hosp, Ctr Sepsis Control & Care, Jena, Germany

[2] Jena Univ Hosp, Clin Anesthesiol & Intens Care, Jena, Germany

[3] Helmholtz Zentrum Muenchen, Inst Expt Genet, German Res Ctr Environm Hlth, German Mouse Clin, Neuherberg, Germany

[4] Ludwig Maximilians Univ Muenchen, Gene Ctr, Chair Mol Anim Breeding & Biotechnol, Munich, Germany

[5] German Ctr Diabet Res, Neuherberg, Germany

[6] Tech Univ Munich, Ctr Life & Food Sci, Chair Expt Genet, Weihenstephan, Freising Weihenstephan, Germany

来源：

JOURNAL OF THE AMERICAN ASSOCIATION FOR LABORATORY ANIMAL SCIENCE | 2016年 / 55卷 / 04期

关键词：

LABORATORY-ANIMALS; REFERENCE VALUES; MOUSE STRAINS; SERUM CHEMISTRY; BLOOD VALUES; FATTY-ACIDS; SUBSTRAINS; HEMATOLOGY; PLASMA; AGE;

D O I：

暂无

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Although various mouse inbred strains are widely used to investigate disease mechanisms and to establish new therapeutic strategies, sex-specific reference intervals for laboratory diagnostic analytes that are generated from large numbers of animals have been unavailable. In this retrospective study, we screened data from more than 12,000 mice phenotyped in the German Mouse Clinic from January 2006 through June 2014 and selected animals with the genetic background of C57BL/6J, C57BL/6N, or C3HeB/FeJ. In addition, we distinguished between the C57BL/6NTac substrain and C57BL/6N mice received from other vendors. The corresponding data sets of electrolytes (sodium, potassium, calcium, chloride, inorganic phosphate), lipids (cholesterol, triglyceride), and enzyme activities (ALT, AST, ALP, alpha-amylase) and urea, albumin, and total protein levels were analyzed. Significant effects of age and sex on these analytes were identified, and strain-or substrain-and sex-specific reference intervals for 90-to 135-d-old mice were calculated. In addition, we include an overview of the literature that reports clinical chemistry values for wild-type mice of different strains. Our results support researchers interpreting clinical chemistry values from various mouse mutants and corresponding wild-type controls based on the examined strains and substrains.

引用

页码：375 / 386

页数：12

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