Viral Kinetic Modeling of Chronic Hepatitis C and B Infection

被引：1

作者：

Herrmann, Eva ^{[1
]}

Asai, Yusuke ^{[1
]}

机构：

[1] Goethe Univ Frankfurt, Dept Med, Inst Biostat & Math Modeling, Frankfurt, Germany

来源：

NONAUTONOMOUS DYNAMICAL SYSTEMS IN THE LIFE SCIENCES | 2013年 / 2102卷

关键词：

Models in medicine; Parameter estimation; Ordinary differential equations; PKPD models; PEGYLATED INTERFERON-ALPHA-2B; DRUG-RESISTANCE; HCV INFECTION; DYNAMICS; RIBAVIRIN; PEGINTERFERON; REPLICATION; LAMIVUDINE; EPIDEMICS;

D O I：

10.1007/978-3-319-03080-7_8

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Chronic infection with hepatitis C or hepatitis B virus are important world-wide health problems leading to long-term damage of the liver. There are, however, treatment options which can lead to viral eradication in hepatitis C or long-term viral suppression in hepatitis B in some patients. Nevertheless, there is still room for improvement. Mathematical compartment models based on ordinary differential equation systems have successfully been applied to improve antiviral treatment. Here, we illustrate how mathematical and statistical analysis of such models influenced clinical research and give an overview on the most important models for hepatitis C and hepatitis B viral kinetics.

引用

页码：251 / 268

页数：18

共 36 条

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