Hypoglycaemic and antioxidant activities of Ficus racemosa Linn. fruits

被引：20

作者：

Jahan, Ismet Ara ^{[1
,2
]}

Nahar, Nilufar ^{[2
]}

Mosihuzzaman, M. ^{[2
]}

Rokeya, Begum ^{[3
]}

Ali, Liaquat ^{[3
]}

Azad Khan, A. K. ^{[3
]}

Makhmur, Talat ^{[4
]}

Iqbal Choudhary, M. ^{[4
]}

机构：

[1] BCSIR Labs Dhaka, Bangladesh Council Sci & Ind Res, Dhaka, Bangladesh

[2] Univ Dhaka, Dept Chem, Dhaka 1000, Bangladesh

[3] Bangladesh Inst Res & Rehabil Diabet Endocrine &, Dhaka, Bangladesh

[4] Univ Karachi, HEJ Res Inst Chem, Int Ctr Chem Sci, Karachi 32, Pakistan

来源：

NATURAL PRODUCT RESEARCH | 2009年 / 23卷 / 04期

关键词：

Ficus racemosa L; hypoglycaemic activity; diabetes; antioxidant activity; DPPH radical scavenging assay; 3-O-(E)-caffeoyl quinate; DRY EXTRACT; PLANT;

D O I：

10.1080/14786410802230757

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The effects of Ficus racemosa Linn. fruit extract and fraction on fasting serum glucose levels of normal, type 1 and type 2 diabetic model rats are presented. The aqueous 80% EtOH extract and its water soluble fraction of F. racemosa fruit did not show any serum glucose lowering effect on non-diabetic and type 2 diabetic rats at the fasting condition, whereas the extract showed significant hypoglycaemic effect on the type 1 diabetic model rats. Both the extract and fraction were consistently active in both non-diabetic and types 1 and 2 diabetic model rats when fed simultaneously with glucose load. On the contrary, they were ineffective in lowering blood glucose levels when fed 30 min prior to glucose load. The 1-BuOH soluble part of the ethanol extract exhibited significant antioxidant activity in DPPH free radical scavenging assay. 3-O-(E)-Caffeoyl quinate (1) was isolated for the first time from this plant, which also showed significant antioxidant activity.

引用

页码：399 / 408

页数：10

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