The Control of Vocal Pitch in Human Laryngeal Motor Cortex

被引:110
作者
Dichter, Benjamin K. [1 ,2 ,3 ]
Breshears, Jonathan D. [1 ,2 ]
Leonard, Matthew K. [1 ,2 ]
Chang, Edward F. [1 ,2 ,3 ]
机构
[1] Univ Calif San Francisco, Weill Inst Neurosci, San Francisco, CA 94158 USA
[2] Univ Calif San Francisco, Dept Neurol Surg, San Francisco, CA 94143 USA
[3] UC Berkeley & UCSF Joint Program Bioengn, Berkeley, CA 94720 USA
关键词
HUMAN SENSORIMOTOR CORTEX; SPEECH; EVOLUTION; VOCALIZATION; ACTIVATION; PATHWAYS; MUSCLES; SYSTEM; AREA;
D O I
10.1016/j.cell.2018.05.016
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
In speech, the highly flexiblemodulation of vocal pitch creates intonation patterns that speakers use to convey linguisticmeaning. Thishuman ability isunique among primates. Here, we used high-density cortical recordings directly from the human brain to determine the encoding of vocal pitch during natural speech. We found neural populations in bilateral dorsal laryngeal motor cortex (dLMC) that selectively encoded produced pitch but not non-laryngeal articulatory movements. This neural population controlled short pitch accents to express prosodic emphasis on a word in a sentence. Other larynx cortical representations controlling voicing and longer pitch phrase contours were found at separate sites. dLMC sites also encoded vocal pitch during a non-speech singing task. Finally, direct focal stimulation of dLMC evoked laryngeal movements and involuntary vocalization, confirming its causal role in feedforward control. Together, these results reveal the neural basis for the voluntary control of vocal pitch in human speech.
引用
收藏
页码:21 / +
页数:20
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