High frequency stimulation of the subthalamic nucleus influences striatal dopaminergic metabolism in the naive rat

被引：59
作者：
Paul, G
Reum, T
Meissner, W
Marburger, A
Sohr, R
Morgenstern, R
Kupsch, A
机构：
[1] Humboldt Univ, Dept Neurol, D-13353 Berlin, Germany
[2] Humboldt Univ, Inst Pharmacol & Toxicol, D-10098 Berlin, Germany
来源：
NEUROREPORT | 2000年 / 11卷 / 03期
关键词：
dopamine; high frequency stimulation; microdialysis; Parkinson's disease; subthalamic nucleus;
D O I：
10.1097/00001756-200002280-00003
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
High frequency stimulation (HFS) of the subthalamic nucleus (STN) can partially alleviate motor symptoms in patients with Parkinson's disease (PD). However, the mechanism of action of HFS is incompletely understood. We investigated the effect of HFS (130 Hz) and low frequency stimulation (LFS, 20 Hz) of the STN on striatal dopaminergic transmission and metabolism using in vivo microdialysis in anaesthetized and freely moving rats. While LFS had no effect, HFS of the STN produced a delayed, stable and intensity-dependent increase of extracellular dopamine metabolites. Striatal extracellular levels of dopamine and 5-HIAA were not influenced by HFS or LFS in the present experimental paradigm. We conclude that HFS of the STN influences striatal dopaminergic metabolism in naive, non-lesioned rats. NeuroReport 11:441-444 (C) 2000 Lippincott Williams & Wilkins.
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收藏
页码：441 / 444
页数：4
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