Electronic Blood Vessel

被引：80

作者：

Cheng, Shiyu ^{[1
,2
,3
,5
]}

Hang, Chen ^{[1
,2
,3
]}

Ding, Li ^{[1
,2
,3
,4
]}

Jia, Liujun ^{[4
]}

Tang, Lixue ^{[3
]}

Mou, Lei ^{[1
,2
,3
]}

Qi, Jie ^{[1
,2
,3
]}

Dong, Ruihua ^{[1
,2
,3
]}

Zheng, Wenfu ^{[3
]}

Zhang, Yan ^{[4
]}

Jiang, Xingyu ^{[1
,2
,3
]}

机构：

[1] Southern Univ Sci & Technol, Dept Biomed Engn, Shenzhen 518055, Guangdong, Peoples R China

[2] Southern Univ Sci & Technol, Shenzhen Bay Lab, Shenzhen 518055, Guangdong, Peoples R China

[3] Univ Chinese Acad Sci, Natl Ctr NanoSci & Technol, Beijing 100190, Peoples R China

[4] Chinese Acad Med Sci & Peking Union Med Coll, Fuwai Hosp, Natl Ctr Cardiovasc Dis, State Key Lab Cardiovasc Dis, Beijing 100037, Peoples R China

[5] Ecole Polytech Fed Lausanne, Inst Bioengn, Sch Engn, CH-1015 Lausanne, Switzerland

来源：

MATTER | 2020年 / 3卷 / 05期

基金：

国家重点研发计划; 中国国家自然科学基金;

关键词：

TISSUE; STRATEGY;

D O I：

10.1016/j.matt.2020.08.029

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Advances in bioelectronics have great potential to address unsolved biomedical problems in the cardiovascular system. By using poly (L-lactide-co-epsilon-caprolactone), which encapsulates liquid metal to make flexible and biodegradable electrical circuitry, we develop an electronic blood vessel that can integrate flexible electronics with three layers of blood-vessel cells, to mimic and go beyond the natural blood vessel. It can improve the endothelialization process through electrical stimulation and can enable controlled gene delivery into specific parts of the blood vessel via electroporation. The electronic blood vessel has excellent biocompatibility in the vascular system and shows great patency 3 months post-implantation in a rabbit model. The electronic blood vessel would be an ideal platform to enable diagnostics and treatments in the cardiovascular system and can greatly empower personalized medicine by creating a direct link of the vascular tissue-machine interface.

引用

收藏

页码：1664 / 1684

页数：21

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