Synthesis and study of 1,3,5-triazine based thiazole derivatives as antimicrobial agents

A series of novel compounds N'-(4-(arylamino)-6-(thiazol-2-ylamino)-1,3,5-triazin-2-yl)isonicotinohydrazides (3a-l) were synthesized by a series of multistep reactions. Newly synthesized compounds have been characterized by IR, H-1 NMR, C-13 NMR and mass spectral data. Antimicrobial screening of title compounds (3a-l) was examined against Gram-positive bacteria (Staphylococcus aureus, Streptococcus pyogenes), Gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa) and three fungi (Candida albicans, Aspergillus niger, Aspergillus clavatus) by using serial broth dilution method. Synthesized compounds showed potent inhibitory action against test organisms. Screened compounds 3k and 3l were associated with considerably higher antibacterial and antifungal activities than commercially used antibiotics. (C) 2012 Production and hosting by Elsevier B.V. on behalf of King Saud University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).