Organization of the mouse and human DC network

被引：123

作者：

Schlitzer, Andreas ^{[1
]}

Ginhoux, Florent ^{[1
]}

机构：

[1] ASTAR, Singapore Immunol Network SIgN, Singapore 138648, Singapore

来源：

CURRENT OPINION IN IMMUNOLOGY | 2014年 / 26卷

关键词：

EPIDERMAL LANGERHANS CELLS; INFLAMMATORY DENDRITIC CELLS; ANTIGEN CROSS-PRESENTATION; REGULATORY T-CELLS; STEADY-STATE; PRESENTING CELLS; LYMPH-NODES; HELPER-CELL; SKIN; RECEPTOR;

D O I：

10.1016/j.coi.2013.11.002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Dendritic cells (DCs) are the most potent antigen sensing and presenting cells in the body and are able to both initiate and fine-tune complex immune responses on a multitude of levels. In this review, we outline recent advances in our understanding of the organization of the DC network in mice and humans, the functional specialization of the DC subsets that compose these networks, and how this has enabled us to begin to elucidate cross-species parallels. Understanding the inter-relationships between DC populations in both man and mouse will ultimately allow us to exploit our knowledge of DC biology for effective therapeutic strategies.

引用

页码：90 / 99

页数：10

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