Continuous Photochemical Cleavage of Linkers for Solid-Phase Synthesis

被引：23

作者：

Hurevich, Mattan ^{[1
]}

Kandasamy, Jeyakumar ^{[1
]}

Ponnappa, Bopanna M. ^{[1
,2
]}

Collot, Mayeul ^{[1
]}

Kopetzki, Daniel ^{[1
]}

McQuade, D. Tyler ^{[1
,3
]}

Seeberger, Peter H. ^{[1
,2
]}

机构：

[1] Max Planck Inst Colloids & Interfaces, D-14476 Golm, Germany

[2] Free Univ Berlin, Inst Chem & Biochem, D-14195 Berlin, Germany

[3] Florida State Univ, Dept Chem & Biochem, Tallahassee, FL 32306 USA

来源：

ORGANIC LETTERS | 2014年 / 16卷 / 06期

关键词：

PROTECTING GROUPS; PEPTIDE-SYNTHESIS; PURIFICATION; TRACELESS;

D O I：

10.1021/ol500530q

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Photo labile linkers are an attractive alternative for solid-phase synthesis because they can be cleaved using light. However, irradiation in a classical batch photoreactor results in incomplete cleavage of the photolabile linkers. It is demonstrated that a continuous flow photoreactor is superior to a batch photoreactor for the cleavage of a linker from polystyrene resin.

引用

页码：1794 / 1797

页数：4

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