Role of NADPH Oxidase-Mediated Reactive Oxygen Species in Podocyte Injury

被引:62
作者
Chen, Shan [1 ]
Meng, Xian-Fang [2 ]
Zhang, Chun [1 ]
机构
[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Dept Nephrol, Wuhan 430022, Peoples R China
[2] Huazhong Univ Sci & Technol, Tongji Med Coll, Dept Neurobiol, Wuhan 430030, Peoples R China
基金
中国国家自然科学基金;
关键词
TO-MESENCHYMAL TRANSITION; FILTRATION BARRIER INJURY; RENIN-ANGIOTENSIN SYSTEM; INTEGRIN-LINKED KINASE; OXIDATIVE STRESS; MINERALOCORTICOID RECEPTOR; REDUCES PROTEINURIA; UP-REGULATION; IN-VIVO; ACTIVATION;
D O I
10.1155/2013/839761
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Proteinuria is an independent risk factor for end-stage renal disease (ESRD) (Shankland, 2006). Recent studies highlighted the mechanisms of podocyte injury and implications for potential treatment strategies in proteinuric kidney diseases (Zhang et al., 2012). Reactive oxygen species (ROS) are cellular signals which are closely associated with the development and progression of glomerular sclerosis. NADPH oxidase is a district enzymatic source of cellular ROS production and prominently expressed in podocytes (Zhang et al., 2010). In the last decade, it has become evident that NADPH oxidase-derived ROS overproduction is a key trigger of podocyte injury, such as renin-angiotensin-aldosterone system activation (Whaley-Connell et al., 2006), epithelial-to-mesenchymal transition (Zhang et al., 2011), and inflammatory priming (Abais et al., 2013). This review focuses on the mechanism of NADPH oxidase-mediated ROS in podocyte injury under different pathophysiological conditions. In addition, we also reviewed the therapeutic perspectives of NADPH oxidase in kidney diseases related to podocyte injury.
引用
收藏
页数:7
相关论文
共 72 条
[1]   NADPH Oxidase-Mediated Triggering of Inflammasome Activation in Mouse Podocytes and Glomeruli During Hyperhomocysteinemia [J].
Abais, Justine M. ;
Zhang, Chun ;
Xia, Min ;
Liu, Qinglian ;
Gehr, Todd W. B. ;
Boini, Krishna M. ;
Li, Pin-Lan .
ANTIOXIDANTS & REDOX SIGNALING, 2013, 18 (13) :1537-1548
[2]   The NOX toolbox: validating the role of NADPH oxidases in physiology and disease [J].
Altenhofer, Sebastian ;
Kleikers, Pamela W. M. ;
Radermacher, Kim A. ;
Scheurer, Peter ;
Hermans, J. J. Rob ;
Schiffers, Paul ;
Ho, Heidi ;
Wingler, Kirstin ;
Schmidt, Harald H. H. W. .
CELLULAR AND MOLECULAR LIFE SCIENCES, 2012, 69 (14) :2327-2343
[3]   The NOX family of ROS-generating NADPH oxidases: Physiology and pathophysiology [J].
Bedard, Karen ;
Krause, Karl-Heinz .
PHYSIOLOGICAL REVIEWS, 2007, 87 (01) :245-313
[4]   Fulvene-5 potently inhibits NADPH oxidase 4 and blocks the growth of endothelial tumors in mice [J].
Bhandarkar, Sulochana S. ;
Jaconi, Marisa ;
Fried, Levi E. ;
Bonner, Michael Y. ;
Lefkove, Benjamin ;
Govindarajan, Baskaran ;
Perry, Betsy N. ;
Parhar, Ravi ;
Mackelfresh, Jamie ;
Sohn, Allie ;
Stouffs, Michael ;
Knaus, Ulla ;
Yancopoulos, George ;
Reiss, Yvonne ;
Benest, Andrew V. ;
Augustin, Hellmut G. ;
Arbiser, Jack L. .
JOURNAL OF CLINICAL INVESTIGATION, 2009, 119 (08) :2359-2365
[5]   Abrogation of oxidative stress improves insulin sensitivity in the Ren-2 rat model of tissue angiotensin II overexpression [J].
Blendea, MC ;
Jacobs, D ;
Stump, CS ;
McFarlane, SI ;
Ogrin, C ;
Bahtyiar, G ;
Stas, S ;
Kumar, P ;
Sha, Q ;
Ferrario, CM ;
Sowers, JR .
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2005, 288 (02) :E353-E359
[6]   Acid Sphingomyelinase Gene Deficiency Ameliorates the Hyperhomocysteinemia-Induced Glomerular Injury in Mice [J].
Boini, Krishna M. ;
Xia, Min ;
Li, Caixia ;
Zhang, Chun ;
Payne, Lori P. ;
Abais, Justine M. ;
Poklis, Justin L. ;
Hylemon, Philip B. ;
Li, Pin-Lan .
AMERICAN JOURNAL OF PATHOLOGY, 2011, 179 (05) :2210-2219
[7]   Nox4 involvement in TGF-beta and SMAD3-driven induction of the epithelial-to-mesenchymal transition and migration of breast epithelial cells [J].
Boudreau, Howard E. ;
Casterline, Benjamin W. ;
Rada, Balazs ;
Korzeniowska, Agnieszka ;
Leto, Thomas L. .
FREE RADICAL BIOLOGY AND MEDICINE, 2012, 53 (07) :1489-1499
[8]   NADPH oxidase is the primary source of superoxide induced by NMDA receptor activation [J].
Brennan, Angela M. ;
Suh, Sang Won ;
Won, Seok Joon ;
Narasimhan, Purnima ;
Kauppinen, Tiina M. ;
Lee, Hokyou ;
Edling, Ylva ;
Chan, Pak H. ;
Swanson, Raymond A. .
NATURE NEUROSCIENCE, 2009, 12 (07) :857-U57
[9]   ANGIOTENSIN AND BRADYKININ PEPTIDES IN THE TGR(MREN-2)27 RAT [J].
CAMPBELL, DJ ;
RONG, P ;
KLADIS, A ;
REES, B ;
GANTEN, D ;
SKINNER, SL .
HYPERTENSION, 1995, 25 (05) :1014-1020
[10]   Calcium entry via TRPC6 mediates albumin overload-induced endoplasmic reticulum stress and apoptosis in podocytes [J].
Chen, Shan ;
He, Fang-Fang ;
Wang, Hui ;
Fang, Zhan ;
Shao, Ning ;
Tian, Xiu-Juan ;
Liu, Jian-She ;
Zhu, Zhong-Hua ;
Wang, Yu-Mei ;
Wang, Sheng ;
Huang, Kai ;
Zhang, Chun .
CELL CALCIUM, 2011, 50 (06) :523-529