Adiponectin and Cardiovascular Disease

被引：173
作者：
Shibata, Rei [1 ]
Ouchi, Noriyuki [2 ]
Murohara, Toyoaki
机构：
[1] Nagoya Univ, Dept Cardiol, Grad Sch Med, Showa Ku, Nagoya, Aichi 4668550, Japan
[2] Boston Univ, Sch Med, Mol Cardiol Whitaker Cardiovasc Inst, Boston, MA 02118 USA
来源：
CIRCULATION JOURNAL | 2009年 / 73卷 / 04期
关键词：
Adiponectin; Cardiovascular disease; Obesity; CORONARY-HEART-DISEASE; ACTIVATED PROTEIN-KINASE; VENTRICULAR DIASTOLIC FUNCTION; ISCHEMIA-REPERFUSION INJURY; IMPAIRED GLUCOSE-TOLERANCE; ADIPOSE-SPECIFIC PROTEIN; MOLECULAR-WEIGHT FORM; BODY-MASS INDEX; INSULIN-RESISTANCE; PLASMA ADIPONECTIN;
D O I：
10.1253/circj.CJ-09-0057
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Obesity is strongly associated with metabolic and cardiovascular disorders. Adiponectin is an adipose-derived plasma protein that is downregulated in subjects with obesity-related disorders. Low levels of adiponectin are associated with the increased prevalence of obesity-linked cardiovascular diseases, including ischemic heart disease and peripheral artery disease. Experimental findings have shown that adiponectin has beneficial effects in the cardiovascular system by directly acting on the component cells of the heart and blood vessels. Adiponectin protects cardiovascular tissues under conditions of stress through a number of mechanisms: inhibition of pro-inflammatory and hypertrophic responses, and stimulation of endothelial cell responses. These effects of adiponectin are mainly attributed to the modulation of signaling molecules, including AMP-activated protein kinase. Thus, adiponectin could be a promising therapeutic target for cardiovascular diseases. (Circ J 2009;73: 608-614)
引用
收藏
页码：608 / 614
页数：7
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